Evidence map›Paper›PMID 20116369›Full record

ArticleBrain research2010

Exercise protects against MPTP-induced neurotoxicity in mice.

Kimberly M Gerecke, Yun Jiao, Amar Pani, Vishwajeeth Pagala, Richard J Smeyne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 108 citations in OpenAlex.

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  19. Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly M GereckeDepartment of Psychology, Rhodes College, Memphis, TN 38112, USA.
Yun Jiao
Amar Pani
Vishwajeeth Pagala
Richard J Smeyne
St. Jude Children's Research Hospital · US

Funding

Mechanisms of Exercise-Induced Protection and Rescue in Models of Dopamine LossR01NS070825 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOFFER, BARRY J, ZIGMOND, MICHAEL J · 2011 to 2014
$2.3M
GENETICS OF MPTP-INDUCED PARKINSONISMR01NS039006 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SMEYNE, RICHARD J · 1999 to 2009
$2.2M
Role of Environment in NeuroprotectionR21NS045906 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SMEYNE, RICHARD J · 2004 to 2005
$368k
NINDS NIH HHS R01 NS039006NINDS NIH HHS R01 NS070825NINDS NIH HHS R21 NS045906
6 · The paper itself

Abstract

Exercise has been shown to be potently neuroprotective in several neurodegenerative models, including 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) model of Parkinson's disease (PD). In order to determine the critical duration of exercise necessary for DA neuroprotection, mice were allowed to run for either 1, 2 or 3months prior to treatment with saline or MPTP. Quantification of DA neurons in the SNpc show that mice allowed to run unrestricted for 1 or 2months lost significant numbers of neurons following MPTP administration as compared to saline treated mice; however, 3months of exercise provided complete protection against MPTP-induced neurotoxicity. To determine the critical intensity of exercise for DA neuroprotection, mice were restricted in their running to either 1/3 or 2/3 that of the full running group for 3months prior to treatment with saline or MPTP. Quantification of DA neurons in the SNpc show that mice whose running was restricted lost significant numbers of DA neurons due to MPTP toxicity; however, the 2/3 running group demonstrated partial protection. Neurochemical analyses of DA and its metabolites DOPAC and HVA show that exercise also functionally protects neurons from MPTP-induced neurotoxicity. Proteomic analysis of SN and STR tissues indicates that 3months of exercise induces changes in proteins related to energy regulation, cellular metabolism, the cytoskeleton, and intracellular signaling events. Taken together, these data indicate that exercise potently protects DA neurons from acute MPTP toxicity, suggesting that this simple lifestyle element may also confer significant protection against developing PD in humans.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsCytoprotectionDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLNerve DegenerationNeuronsNeurotoxinsParkinsonian DisordersPhysical Conditioning, AnimalSubstantia NigraTreatment Outcome1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNeurotoxins

Identifiers

PMID20116369
PMCPMC2884060
OpenAlexW2014078610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.