Evidence map›Paper›PMID 20114047›Full record

ArticleFEBS letters2010

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

Giorgio Gorini, Olga Ponomareva, Kevin S Shores, Maria D Person, R Adron Harris, R Dayne Mayfield

Abstract read
In one paragraph

Article in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
  5. Article
  6. Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021
    Review
  7. Article
  8. The synaptic pathology of cognitive life
.Dialogues in clinical neuroscience · 2019
    Review
  9. Article
  10. The mitochondrial BKMitochondrion · 2017
    Article
  11. Review
  12. Article
  13. Article
  14. BK Channels in the Central Nervous System.International review of neurobiology · 2016
    Review
  15. Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  16. Article
  17. Article
  18. Proteomic approaches and identification of novel therapeutic targets for alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giorgio GoriniWaggoner Center for Alcohol and Addiction Research, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA. gorini@mail.utexas.edu
Olga Ponomareva
Kevin S Shores
Maria D Person
R Adron Harris
R Dayne Mayfield

Funding

Alcohol-responsive protein networks underlying excessive ethanol consumptionU01AA016648 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MAYFIELD, R. DAYNE · 2006 to 2010
$776k
NIAAA NIH HHS AA016648NIAAA NIH HHS U01 AA016648
6 · The paper itself

Abstract

In every synapse, a large number of proteins interact with other proteins in order to carry out signaling and transmission in the central nervous system. In this study, we used interaction proteomics to identify novel synaptic protein interactions in mouse cortical membranes under native conditions. Using immunoprecipitation, immunoblotting, and mass spectrometry, we identified a number of novel synaptic protein interactions involving soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), calcium-activated potassium channel (BKCa) alpha subunits, and dynamin-1. These novel interactions offer valuable insight into the protein-protein interaction network in intact synapses that could advance understanding of vesicle trafficking, release, and recycling.

Indexed as

ProteomicsAnimalsBrainDynamin IImmunoblottingImmunoprecipitationMaleMass SpectrometryMicePotassium Channels, Calcium-ActivatedProtein BindingSNARE ProteinsSynapsesVesicle-Associated Membrane Protein 2Dynamin IPotassium Channels, Calcium-ActivatedSNARE ProteinsVesicle-Associated Membrane Protein 2

Identifiers

PMID20114047
PMCPMC2828775

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.