ArticleExperimental eye research2010
Spectral domain optical coherence tomography in a murine retinal detachment model.
Article in Experimental eye research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Retinal Changes before and after Silicone Oil Removal in Eyes with Rhegmatogenous Retinal Detachment Using Swept-Source Optical Coherence Tomography.Journal of clinical medicine · 2021Article
- Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.Investigative ophthalmology & visual science · 2021Article
- Macular Ganglion Cell Layer Thickness after Macula-Off Rhegmatogenous Retinal Detachment Repair: Scleral Buckling versus Pars Plana Vitrectomy.Journal of clinical medicine · 2020Article
- Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment.Investigative ophthalmology & visual science · 2019Article
- MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment.Scientific reports · 2017Article
- Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130.Journal of neuroinflammation · 2017Article
- Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment.Investigative ophthalmology & visual science · 2014Article
- Article
- Functional and morphological analysis of the subretinal injection of human retinal progenitor cells under Cyclosporin A treatment.Molecular vision · 2014Article
- Retinal detachment model in rodents by subretinal injection of sodium hyaluronate.Journal of visualized experiments : JoVE · 2013Article
- Retinal Thickness Normative Data in Wild-Type Mice Using Customized Miniature SD-OCT.PloS one · 2013Article
- Fundus autofluorescence findings in a mouse model of retinal detachment.Investigative ophthalmology & visual science · 2012Article
- Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomography.Investigative ophthalmology & visual science · 2012Article
- Functional and morphological analysis of the subretinal injection of retinal pigment epithelium cells.Visual neuroscience · 2012Article
- A chick model of retinal detachment: cone rich and novel.PloS one · 2012Article
- Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene.Investigative ophthalmology & visual science · 2011Article
- Spectral Domain OCT: An Aid to Diagnosis and Surgical Planning of Retinal Detachments.Journal of ophthalmology · 2011Article
- Reproducibility of spectral-domain optical coherence tomography total retinal thickness measurements in mice.Investigative ophthalmology & visual science · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Spectral domain optical coherence tomography (SD-OCT) was used to image retinal detachments in vivo, in a murine model of retinal detachment (RD). Subretinal injections of hyaluronic acid (Healon) were delivered to the right eye of seventeen 10-20 week-old C57Bl6 mice. Evaluation of the fundus with an operating microscope and fundus photography were performed. In vivo, non-contact, ultra high resolution SD-OCT imaging was performed on day 0, day 1-2, day 5-6 and day 15-16. The retinal morphology at the edge and in the area of maximal RD was evaluated. Eyes were enucleated for histologic analysis. The retinal detachment was confirmed by microscopy in all mice. The extent of the retinal detachment was evaluated by measuring the height of the retinal detachment. The retinal layers, including the photoreceptor layer, were evaluated. Retinal layers appeared indistinct soon after RD (day 1, 5), particularly over areas of maximal detachment. By day 5 and 15 the external limiting membrane was no longer visible and there was increased reflectivity of the photoreceptor layer and undulation of the outer retina in areas of RD on both SD-OCT and histology. The thickness of the outer nuclear layer and photoreceptor outer segments decreased on day 5 and 15. SD-OCT is a promising technology to follow retinal detachment and outer retinal abnormalities in a murine model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.