Trial reportTransfusion2010
Predonation hydration and applied muscle tension combine to reduce presyncopal reactions to blood donation.
Trial report in Transfusion, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02075099 (Evaluation of the Efficiency of a Hydration by Isotonic Solution With or Without Muscular Exercise of the Fainting Whole Blood Donors), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Efficiency of a Hydration by Isotonic Solution With or Without Muscular Exercise of the Fainting Whole Blood Donors
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prevention of Blood Donation-related Vasovagal Response by Applied Muscle Tension: a Meta-analysis.The Journal of international medical research · 2022Pooled it
- Interventions for Individuals With High Levels of Needle Fear: Systematic Review of Randomized Controlled Trials and Quasi-Randomized Controlled Trials.The Clinical journal of pain · 2015Pooled it
- Water administration and the risk of syncope and presyncope during blood donation: a randomized clinical trial.Transfusion · 2012Trial
- Article
- Application of predonation hydration for vasovagal reactions during blood donation: a bibliometric analysis (2004-2023).Frontiers in medicine · 2025Article
- Machine learning-based prediction of fainting during blood donations using donor properties and weather data as features.BMC medical informatics and decision making · 2022Article
- Delayed Vasovagal Reaction with Reflex Syncope Following COVID-19 Vaccination.Internal medicine (Tokyo, Japan) · 2022Article
- Vasovagal reactions in whole blood and apheresis donors: a cross-sectional study on donor haemovigilance data from 2016 to 2019 in Italy.Blood transfusion = Trasfusione del sangue · 2022Article
- Penicillin Reactions in Patients With Severe Rheumatic Heart Disease: A Presidential Advisory From the American Heart Association.Journal of the American Heart Association · 2022Article
- Counter pressure maneuvers for syncope prevention: A semi-systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Review
- Effects of Performing Applied Muscle Tension during Recovery after Phlebotomy in Young, First-Time Donors: A Pilot Study.International journal of environmental research and public health · 2021Article
- Beyond Description: The Predictive Role of Affect, Memory, and Context in the Decision to Donate or Not Donate Blood.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Review
- Development of an Intervention to Reduce Pain and Prevent Syncope Related to Adolescent Vaccination.The Permanente journal · 2019Article
- Water ingestion decreases cardiac workload time-dependent in healthy adults with no effect of gender.Scientific reports · 2017Article
- Article
- Hemodynamic response during standing test after blood donation can predict the late phase vasovagal reaction.Heart and vessels · 2016Article
- Women as whole blood donors: offers, donations and deferrals in the province of Huelva, south-western Spain.Blood transfusion = Trasfusione del sangue · 2014Article
- Donor anxiety, needle pain, and syncopal reactions combine to determine retention: a path analysis of two-year donor return data.Transfusion · 2013Article
- Vasovagal reactions in whole blood donors at three REDS-II blood centers in Brazil.Transfusion · 2012Article
- Complications related to blood donation: A multicenter study of the prevalence and influencing factors in voluntary blood donation camps in Karnataka, India.Asian journal of transfusion scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA randomized controlled trial was conducted to test the effects of hydration and applied muscle tensing on presyncopal reactions to blood donation. Both interventions are designed to prevent the decreases in blood pressure that can contribute to such reactions, but due to the distinct physiologic mechanisms underlying their pressor responses it was hypothesized that a combined intervention would yield the greatest benefit. STUDY DESIGN AND
methodsBefore blood donation, first- and second-time blood donors (mean age, 20.2 years; SD, 4.9) were randomly assigned to 1) standard donation, 2) placebo (leg exercise before venipuncture), 3) predonation water, or 4) predonation water and leg exercise during donation.
resultsMain effects of group were observed for phlebotomist classification of vasovagal reactions (chi(2)(3) = 8.38, p < 0.05) and donor reports of presyncopal reactions (chi(2)(3) = 13.16, p < 0.01). Follow-up analyses of phlebotomist classifications revealed fewer reactions in the predonation water and predonation water and leg exercise groups relative to placebo but not standard donation. Follow-up analyses of self-reported reactions revealed that women, but not men, had lower scores in both the predonation water and the predonation water and leg exercise groups relative to both placebo and standard donation.
conclusionsPredonation hydration and a combination of hydration and leg exercise may help attenuate presyncopal reactions in relatively novice donors, although future studies with larger samples are required to confirm this effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.