ArticleInsect molecular biology2010
Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration.
Article in Insect molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Compound effector genes suppress malaria parasite infections in gene-drive population modification strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii.G3 (Bethesda, Md.) · 2026Article
- History of Mosquito Transgenesis: A Perspective in Review.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Article
- ImprovedInternational journal of molecular sciences · 2023Article
- Dual effector population modification gene-drive strains of the African malaria mosquitoes,Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti.Scientific reports · 2023Article
- Mathematical modeling of the performance of wild and transgenic mosquitoes in malaria transmission.PloS one · 2023Article
- Next-generation tools to control biting midge populations and reduce pathogen transmission.Parasites & vectors · 2021Review
- Assessment of Developmental and Reproductive Fitness of Dengue-Resistant TransgenicBioMed research international · 2021Article
- Characterization of a female germline and early zygote promoter from the transcription factor bZip1 in the dengue mosquito Aedes aegypti.Parasites & vectors · 2020Article
- Experimental population modification of the malaria vector mosquito, Anopheles stephensi.PLoS genetics · 2019Article
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Modeling the spreading and interaction between wild and transgenic mosquitoes with a random dispersal.PloS one · 2018Article
- nanos-Driven expression of piggyBac transposase induces mobilization of a synthetic autonomous transposon in the malaria vector mosquito, Anopheles stephensi.Insect biochemistry and molecular biology · 2017Article
- GUY1 confers complete female lethality and is a strong candidate for a male-determining factor ineLife · 2016Article
- Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Increased Akt signaling in the mosquito fat body increases adult survivorship.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes.Insects · 2015Review
- Engineering the control of mosquito-borne infectious diseases.Genome biology · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Genetically modified mosquitoes that are unable to transmit pathogens offer opportunities for controlling vector-borne diseases such as malaria and dengue. Site-specific gene recombination technologies are advantageous in the development of these insects because antipathogen effector genes can be inserted at integration sites in the genome that cause the least alteration in mosquito fitness. Here we describe Anopheles stephensi transgenic lines containing phi C31 attP'docking' sites linked to a fluorescent marker gene. Chromosomal insertion sites were determined and life-table parameters were assessed for transgenic mosquitoes of each line. No significant differences in fitness between the transgenic and nontransgenic mosquitoes were detected in this study. These transgenic lines are suitable for future site-specific integrations of antiparasite transgenes into the attP sites.
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