ReviewJournal of neurovirology2010
Herpes simplex virus type 1 and Bell's palsy-a current assessment of the controversy.
Review in Journal of neurovirology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Efficacy of photobiomodulation therapy on Bell's palsy symptoms: a systematic review.Lasers in medical science · 2024Pooled it
- Efficacy and Safety of Pharmacological and Physical Therapies for Bell's Palsy: A Bayesian Network Meta-Analysis.Frontiers in neurology · 2022Pooled it
- 3D T1-Weighted Black-Blood MRI in the Diagnosis and Follow-Up of Facial Neuritis: a Single-Center Prospective Study.Clinical neuroradiology · 2025Article
- Evaluation of the Systemic Inflammation in Patients with Bell's Palsy: Monocyte-to-High-Density Lipoprotein Cholesterol Ratio and Hematologic Indices of Inflammation.Journal of clinical medicine · 2025Article
- Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies.Biomedicines · 2025Article
- Integrative therapy for acute, subacute and chronic facial palsy: repeated differential facial nerve blocks combined with hypodermic needle-based facial nerve stimulation.Frontiers in neurology · 2025Article
- Alterations in pathogen-specific cellular and humoral immunity associated with acute peripheral facial palsy of infectious origin.Journal of neuroinflammation · 2023Observational
- A Prospective Study on Post Covid Sudden Onset Sensory Neural Hearing Loss and Its Recovery.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The Incidence of Sudden Sensorineural Hearing Loss (SSNHL) in COVID-19 Patients in Tertiary Care Referral Units.SN comprehensive clinical medicine · 2023Article
- Bell's palsy with Herpes simplex disciform keratitis: A case report.American journal of ophthalmology case reports · 2022Article
- Does SARS-CoV-2 affect cochlear functions in children?Saudi medical journal · 2022Article
- Sudden Sensorineural Hearing Loss in Mild COVID-19: Case Series and Analysis of the Literature.Audiology research · 2021Article
- Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection.PLoS pathogens · 2021Article
- Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy.The journal of physiological sciences : JPS · 2020Article
- Infectious causes of peripheral facial nerve palsy in children-a retrospective cohort study with long-term follow-up.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Neurological disorders and inflammatory bowel diseases.World journal of gastroenterology · 2014Review
- The alterations of matrix metalloproteinase-9 in mouse brainstem during herpes simplex virus type 1-induced facial palsy.Journal of molecular neuroscience : MN · 2013Article
- Virome genomics: a tool for defining the human virome.Current opinion in microbiology · 2013Review
- Imaging the facial nerve: a contemporary review.Radiology research and practice · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bell's palsy causes about two thirds of cases of acute peripheral facial weakness. Although the majority of cases completely recover spontaneously, about 30% of cases do not and are at risk from persisting severe facial paralysis and pain. It has been suggested that herpes simplex virus type 1 (HSV-1) may be the etiological agent that causes Bell's palsy. Although corticosteroid therapy is now universally recognized as improving the outcome of Bell's palsy, the question as to whether or not a combination of antiviral agents and corticosteroids result in a better rate of complete facial recovery compared with corticosteroids alone is now a highly contentious issue. The evidence obtained from laboratory studies of animals and humans that HSV-1 may be linked to facial nerve paralysis is first outlined. The discussion then focuses on the results of different clinical trials of the efficacy of antiviral agents combined with corticosteroids in increasing the rate of complete recovery in Bell's palsy. These have often given different results leading to opposite conclusions as to the efficacy of antivirals. Of three recent meta-analyses of previous trials, two concluded that antivirals produce no added benefit to corticosteroids alone in producing complete facial recovery, and one concluded that such combined therapy may be associated with additional benefit. Although it is probably not justified at the present time to treat patients with Bell's palsy with antiviral agents in addition to corticosteroids, it remains to be shown whether antivirals may be beneficial in treating patients who present with severe or complete facial paralysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.