ArticleCellular and molecular life sciences : CMLS2010
Novel role of cPLA(2)alpha in membrane and actin dynamics.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- The Emerging Role of Macrophages in Immune System Dysfunction under Real and Simulated Microgravity Conditions.International journal of molecular sciences · 2021Review
- Roles of microglial membranes in Alzheimer's disease.Current topics in membranes · 2020Article
- Cytosolic Phospholipase AMolecular neurobiology · 2019Article
- Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography.Journal of cellular physiology · 2018Article
- Oxidative-stress induced increase in circulating fatty acids does not contribute to phospholipase A2-dependent appetitive long-term memory failure in the pond snail Lymnaea stagnalis.BMC neuroscience · 2014Article
- Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma.Progress in lipid research · 2013Review
- Effects of simulated microgravity on primary human NK cells.Astrobiology · 2013Article
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology.Astrobiology · 2013Review
- Functions and regulation of circular dorsal ruffles.Molecular and cellular biology · 2012Review
- TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling.Oncogene · 2012Article
- Article
- Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling.Biophysical journal · 2011Article
- Attachment of HeLa cells during early G1 phase.Histochemistry and cell biology · 2011Article
- Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease.Journal of neurochemistry · 2011Review
- Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis.Journal of the National Cancer Institute · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin-directed processes such as membrane ruffling and cell migration are regulated by specific signal transduction pathways that become activated by growth factor receptors. The same signaling pathways that lead to modifications in actin dynamics also activate cPLA(2)alpha. Moreover, arachidonic acid, the product of cPLA(2)alpha activity, is involved in regulation of actin dynamics. Therefore, it was investigated whether cPLA(2)alpha plays a role in actin dynamics, more specifically during growth factor-induced membrane ruffling and cell migration. Upon stimulation of ruffling and cell migration by growth factors, endogenous cPLA(2)alpha and its active phosphorylated form were shown to relocate at protrusions of the cell membrane involved in actin and membrane dynamics. Inhibition of cPLA(2)alpha activity with specific inhibitors blocked growth factor-induced membrane and actin dynamics, suggesting an important role for cPLA(2)alpha in these processes.
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