ArticleDiabetologia2010
Independent effects of weight gain and fetal programming on metabolic complications in adults born small for gestational age.
Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- When is birthweight at term (≥37 weeks' gestation) abnormally low? A systematic review and meta-analysis of the prognostic and predictive ability of current birthweight standards for childhood and adult outcomes.BJOG : an international journal of obstetrics and gynaecology · 2015Pooled it
- Nongenetic determinants of age at menarche: a systematic review.BioMed research international · 2014Pooled it
- Long-term health in individuals born preterm or with low birth weight: A cohort study.Pediatric research · 2025Article
- [Short stature due to intrauterine growth retardation. Clinical and hormonal-metabolic features, possibilities of growth-stimulating therapy].Problemy endokrinologii · 2022Article
- First Year Metabolic and Hormonal Behavior Define two Different Populations of SGA Newborn for Weight or Height.Journal of the Endocrine Society · 2022Article
- Extreme Birth Weight and Metabolic Syndrome in Children.Nutrients · 2022Observational
- P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.BMC medicine · 2021Article
- A comparison of the growth status, level of blood glucose, and lipid metabolism in small for gestational age and appropriate for gestational age girls with central precocious puberty: a retrospective study.Translational pediatrics · 2021Article
- Rapid BMI Increases and Persistent Obesity in Small-for-Gestational-Age Infants.Frontiers in pediatrics · 2021Article
- Effects of Oral Glutamine Supplementation on Early Postnatal Muscle Morphology in Low and Normal Birth Weight Piglets.Animals : an open access journal from MDPI · 2020Article
- Prenatal over- and undernutrition differentially program small intestinal growth, angiogenesis, absorptive capacity, and endocrine function in sheep.Physiological reports · 2020Article
- Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring.Neuroscience · 2019Article
- Growth of infants and young children born small for gestational age: growth restriction accompanied by overweight.The Journal of international medical research · 2018Article
- Long-term metabolic risk among children born premature or small for gestational age.Nature reviews. Endocrinology · 2017Review
- Prevalence of diabetes and obesity in association with prematurity and growth restriction.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
- Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort.BMJ open · 2016Article
- Dietary intake in young adults born small or appropriate for gestational age: data from the Haguenau cohort.BMJ open · 2016Article
- SGA children with moderate catch-up growth are showing the impaired insulin secretion at the age of 4.PloS one · 2014Article
- Article
- Is the metabolic syndrome a "small baby" syndrome?: the bogalusa heart study.Metabolic syndrome and related disorders · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisInsulin resistance (IR) and the metabolic syndrome (MS) have been reported in adults as a consequence of being born small for gestational age (SGA). The process seems to be initiated early in life; however, little is known about the progression of MS and IR in young adults. We hypothesised that being born SGA would promote a greater progression over time of IR and MS, reflecting not only the gain in weight and fat mass but also the extension of the fetal programming process.
methodsParticipants were selected from a community-based cohort and born full-term either SGA (birthweight <10th percentile) or appropriate for gestational age (25th < birthweight < 75th percentile). A total of 1,308 individuals were prospectively followed between the ages of 22 and 30 years.
resultsAt both ages, individuals born SGA were more insulin-resistant and showed a significantly higher prevalence of MS. Over the 8 year follow-up, the risk of developing MS was twofold higher in those SGA, after adjustment for gain in BMI, whereas the progression of IR was not significantly affected by the birth status. CONCLUSIONS/
interpretationOur data suggest that metabolic disorders in SGA individuals are amplified by the weight gain with time when adults, both probably resulting from fetal programming. Moreover, the modest increase in IR contrasts with the constant and much higher prevalence of MS.
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