ArticleJournal of biomedicine & biotechnology2010
The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- The role of the AHR in host-pathogen interactions.Nature reviews. Immunology · 2025Review
- Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry.Journal for immunotherapy of cancer · 2022Article
- Human Adult Microbiota in a Static Colon Model: AhR Transcriptional Activity at the Crossroads of Host-Microbe Interaction.Foods (Basel, Switzerland) · 2022Article
- Rodent genetic models of Ah receptor signaling.Drug metabolism reviews · 2021Review
- Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis.Clinical microbiology reviews · 2021Review
- The aryl hydrocarbon receptor and the gut-brain axis.Cellular & molecular immunology · 2021Review
- Review
- Article
- Aryl Hydrocarbon Receptor-Signaling Regulates EarlyFrontiers in immunology · 2019Article
- Activation of aryl hydrocarbon receptor regulates the LPS/IFNγ-induced inflammatory response by inducing ubiquitin-proteosomal and lysosomal degradation of RelA/p65.Biochemical pharmacology · 2018Article
- Review
- Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases.BioMed research international · 2018Review
- The Aryl Hydrocarbon Receptor Modulates Production of Cytokines and Reactive Oxygen Species and Development of Myocarditis during Trypanosoma cruzi Infection.Infection and immunity · 2016Article
- Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization.Life sciences · 2016Article
- A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.Oncoimmunology · 2016Article
- CD73-generated adenosine is critical for immune regulation during Toxoplasma gondii infection.Infection and immunity · 2015Article
- Article
- Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection.Infection and immunity · 2014Article
- The aryl hydrocarbon receptor promotes IL-10 production by NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The aryl hydrocarbon receptor in innate T cell immunity.Seminars in immunopathology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aryl hydrocarbon receptor (AhR) is part of a signaling system that is mainly triggered by xenobiotic agents. Increasing evidence suggests that AhR may regulate immunity to infections. To determine the role of AhR in the outcome of toxoplasmosis, we used AhR-/- and wild-type (WT) mice. Following an intraperitoneal infection with Toxoplasma gondii (T. gondii), AhR-/- mice succumbed significantly faster than WT mice and displayed greater liver damage as well as higher serum levels of tumor necrosis factor (TNF)-alpha, nitric oxide (NO), and IgE but lower IL-10 secretion. Interestingly, lower numbers of cysts were found in their brains. Increased mortality was associated with reduced expression of GATA-3, IL-10, and 5-LOX mRNA in spleen cells but higher expression of IFN-gamma mRNA. Additionally, peritoneal exudate cells from AhR-/- mice produced higher levels of IL-12 and IFN-gamma but lower TLR2 expression than WT mice. These findings suggest a role for AhR in limiting the inflammatory response during toxoplasmosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.