ArticleAsian journal of andrology2010
Semen analysis in 21st century medicine: the need for sperm function testing.
Article in Asian journal of andrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Sperm capacitation ability, as evaluated by Cap-Score™, has little impact on ICSI success.Journal of assisted reproduction and genetics · 2026Article
- Sperm DNA Fragmentation and Fertility.Advances in experimental medicine and biology · 2025Review
- Male infertility.Nature reviews. Disease primers · 2023Review
- Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines.International journal of molecular sciences · 2023Review
- Sperm Adhesion Molecule 1 (SPAM1) Distribution in Selected Human Sperm by Hyaluronic Acid Test.Biomedicines · 2022Article
- Evolution of the WHO "Semen" processing manual from the first (1980) to the sixth edition (2021).Fertility and sterility · 2022Review
- Oxidative Stress and Male Infertility: Evidence From a Research Perspective.Frontiers in reproductive health · 2022Review
- Cytochemical tests to investigate sperm DNA damage: Assessment and review.Journal of family medicine and primary care · 2019Review
- Cap-Score™ prospectively predicts probability of pregnancy.Molecular reproduction and development · 2018Observational
- Comparative Proteomics Reveal the Association between SPANX Proteins and Clinical Outcomes of Artificial Insemination with Donor Sperm.Scientific reports · 2018Article
- Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.Oxidative medicine and cellular longevity · 2018Article
- Localization patterns of the ganglioside GMolecular reproduction and development · 2017Article
- Validation of a laboratory-developed test of human sperm capacitation.Molecular reproduction and development · 2017Article
- Evaluating a novel panel of sperm function tests for utility in predicting intracytoplasmic sperm injection (ICSI) outcome.Journal of assisted reproduction and genetics · 2013Article
- Sperm parameters: paradigmatic index of good health and longevity.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Review
- Sperm chromatin structure assay results after swim-up are related only to embryo quality but not to fertilization and pregnancy rates following IVF.Asian journal of andrology · 2011Article
- Flow cytometry for the assessment of animal sperm integrity and functionality: state of the art.Asian journal of andrology · 2011Review
- New WHO-reference limits-revolution or storm in a teapot?Asian journal of andrology · 2011Article
- Semen analysis and sperm function tests: How much to test?Indian journal of urology : IJU : journal of the Urological Society of India · 2011Article
- Afterword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology.Asian journal of andrology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Sperm function testing, once commonly performed for the infertile couple before employing assisted reproductive technology (ART), has fallen out of favour in many reproductive medicine centers throughout the world. Indeed, the most recent addition of the 'World Health Organisation (WHO) Laboratory Manual for the Examination and Processing of Human Semen' now groups many of these procedures into a section termed Research Procedures. In large part, this reflects the current clinical practice of bypassing the in-depth evaluation of the male partner, while assuming that if a spermatozoon can be found for intracytoplasmic sperm injection (ICSI), it must be a healthy cell capable of achieving fertilization. Nevertheless, sperm function testing can provide valuable clinical insights into defects causing male infertility. Admittedly, in some cases, functional sperm deficiencies can be overcome using an ART. In other cases, couples will be empowered by the knowledge of the cause of their infertility, and for some couples, perhaps even the likelihood of ICSI success (relative to the spermatozoa). The knowledge allows them to make truly informed reproductive decisions, including (perhaps) the decision to seek donor insemination, to adopt or to remain childless. Knowledge of the cause of their infertility may provide closure for couples and a sense of confidence regarding their choice of reproductive treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.