ArticleAsian journal of andrology2010
Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen.
Article in Asian journal of andrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparing fertilization rates from intracytoplasmic sperm injection to conventional in vitro fertilization among women of advanced age with non-male factor infertility: a meta-analysis.Fertility and sterility · 2020Pooled it
- Pooled it
- Protective Effects ofAntioxidants (Basel, Switzerland) · 2026Article
- Association of EEF1A1 and linc00993 expression with sperm morphology in teratozoospermia: an integrative in silico and in vitro study.Scientific reports · 2026Article
- The Cryoprotectant Effects of Safflower Polysaccharides on the Quality of Frozen-Thawed Boar Sperm.Animals : an open access journal from MDPI · 2025Article
- Propolis mitigates busulfan-induced testicular dysfunction in rats: insights into redox stabilization, PCNA modulation, and caspase-3 inhibition.Frontiers in pharmacology · 2025Article
- Zinc Supplementation Reduces Testicular Cell Apoptosis in Mice and Improves Spermatogenic Dysfunction Caused by Marginal Zinc Deficiency.Biological trace element research · 2024Article
- Association of Urinary Mycotoxins with Sperm Quality: A Case-Control Study in Southern Nigeria.Toxins · 2024Article
- Sperm morphology by strict criteria does not predict clinical pregnancy rate following intra-uterine insemination.Arab journal of urology · 2024Article
- Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.Reproductive biology and endocrinology : RB&E · 2023Article
- Seminal Calbindin 2 in Infertile Men With Varicocele: A Prospective Comparative Study.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Changes in Semen Analysis over Time: A Temporal Trend Analysis of 20 Years of Subfertile Non-Azoospermic Men.The world journal of men's health · 2023Article
- Assisted Oocyte Activation following Intracytoplasmic Sperm Injection: A Sensible Option for Infertile Couples with Severe Teratozoospermia.International journal of fertility & sterility · 2023Article
- Evaluation of sperm counting accuracy on computer-assisted sperm analysis with GoldCyto® slides and glass slides.Frontiers in veterinary science · 2023Article
- Decline of Sperm Quality over the Last Two Decades in the South of Europe: A Retrospective Study in Infertile Patients.Biology · 2022Article
- Article
- Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training.The world journal of men's health · 2022Review
- Reproductive effects of sulfoxaflor in male Sprague Dawley rats.Environmental science and pollution research international · 2022Article
- Spermatic Microbiome Characteristics in Infertile Patients: Impact on Sperm Count, Mobility, and Morphology.Journal of clinical medicine · 2022Article
- Evolution of the WHO "Semen" processing manual from the first (1980) to the sixth edition (2021).Fertility and sterility · 2022Review
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Abstract
The very low cut-off value for sperm morphology of 4% morphologically normal spermatozoa, as proposed in the new edition of the World Health Organization (WHO) manual on semen analysis, is in agreement with recently published values and reflects the trend of a decline in reported mean values for normal sperm morphology. The reduced value for morphologically normal spermatozoa over the years may be due to several factors. The first is the introduction of strict criteria for the evaluation of sperm morphology. Other reasons may include the introduction of additional criteria for sperm morphology abnormalities and the suggested decrease in semen parameters because of increasing negative environmental influences. Although on its own the newly proposed very low normal value may not provide the strong predictive value for a males' fertility potential, as originally reported for sperm morphology evaluated according to strict criteria, a good predictive value can still be obtained if the holistic, strict approach for sperm morphology evaluation is followed together with additional sperm morphology parameters now available, because certain morphology patterns and sperm abnormalities are now known to be of strong prognostic value. In addition, better international standardization of the technical methodology, consensus on the interpretation of sperm morphology evaluation criteria and standardized international external quality control (EQC) schemes, are of utmost importance to maintain the good predictive value of sperm morphology.
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