ArticleEMBO reports2010
Ionotropic and metabotropic mechanisms in chemoreception: 'chance or design'?
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 105 citations in OpenAlex.
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- Potential Therapeutic Applications of Synthetic Conotoxin s-cal14.2b, Derived fromBiomedicines · 2021Article
- Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster.PLoS genetics · 2021Article
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- Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.Molecular biology reports · 2021Article
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- Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.Molecular neurobiology · 2020Article
- Characterizing human odorant signals: insights from insect semiochemistry andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Machine learning decodes chemical features to identify novel agonists of a moth odorant receptor.Scientific reports · 2020Article
- ON selectivity in theeLife · 2019Article
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- Whole-head recording of chemosensory activity in the marine annelidOpen biology · 2018Article
- A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift.Ecology and evolution · 2018Article
- High Precision of Spike Timing across Olfactory Receptor Neurons Allows Rapid Odor Coding in Drosophila.iScience · 2018Article
- Comparative study of chemical neuroanatomy of the olfactory neuropil in mouse, honey bee, and human.Biological cybernetics · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemosensory receptors convert an enormous diversity of chemical signals from the external world into a common language of electrical activity in the brain. Mammals and insects use several families of transmembrane receptor proteins to recognize distinct classes of volatile and non-volatile chemicals that are produced by conspecifics or other environmental sources. A comparison of the signalling mechanisms of mammalian and insect receptors has revealed an unexpected functional distinction: mammals rely almost exclusively on metabotropic ligand-binding receptors, which use second messenger signalling cascades to indirectly activate ion channels, whereas insects use ionotropic receptors, which are gated directly by chemical stimuli, thereby leading to neuronal depolarization. In this review, we consider possible reasons for this dichotomy, taking into account biophysical, cell biological, ecological and evolutionary influences on how information is extracted from chemosensory cues by these animal classes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.