ArticleThe EMBO journal2010
Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes.Science advances · 2025Article
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- Cell entry of bovine respiratory syncytial virus through clathrin-mediated endocytosis is regulated by PI3K-Akt and Src-JNK pathways.Frontiers in microbiology · 2024Article
- Genome-Wide Analysis inGenes · 2022Article
- In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.Development (Cambridge, England) · 2021Article
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- The synaptic life of microtubules.Current opinion in neurobiology · 2021Review
- Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq.eLife · 2019Article
- Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications.Drug design, development and therapy · 2019Review
- A Quantitative Model for BicD2/Cargo Interactions.Biochemistry · 2018Article
- Inhibition of endocytic pathways impacts cytomegalovirus maturation.Scientific reports · 2017Article
- Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.American journal of human genetics · 2017Article
- Decreased function of survival motor neuron protein impairs endocytic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias.Frontiers in molecular neuroscience · 2016Review
- Mitochondrial retrograde signaling regulates neuronal function.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Efficient Endocytic Uptake and Maturation in Drosophila Oocytes Requires Dynamitin/p50.Genetics · 2015Article
- Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.Brain : a journal of neurology · 2015Article
- Mechanism and regulation of cytoplasmic dynein.Annual review of cell and developmental biology · 2015Review
- Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophies.Brain : a journal of neurology · 2014Review
- Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.The EMBO journal · 2014Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Cargo transport by microtubule-based motors is essential for cell organisation and function. The Bicaudal-D (BicD) protein participates in the transport of a subset of cargoes by the minus-end-directed motor dynein, although the full extent of its functions is unclear. In this study, we report that in Drosophila zygotic BicD function is only obligatory in the nervous system. Clathrin heavy chain (Chc), a major constituent of coated pits and vesicles, is the most abundant protein co-precipitated with BicD from head extracts. BicD binds Chc directly and interacts genetically with components of the pathway for clathrin-mediated membrane trafficking. Directed transport and subcellular localisation of Chc is strongly perturbed in BicD mutant presynaptic boutons. Functional assays show that BicD and dynein are essential for the maintenance of normal levels of neurotransmission specifically during high-frequency electrical stimulation and that this is associated with a reduced rate of recycling of internalised synaptic membrane. Our results implicate BicD as a new player in clathrin-associated trafficking processes and show a novel requirement for microtubule-based motor transport in the synaptic vesicle cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.