ArticleNature2010
Systemic signals regulate ageing and rejuvenation of blood stem cell niches.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 132 citations in OpenAlex.
- From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.Bone research · 2026Review
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Extracellular Vesicles and Cardiac Aging.Advances in experimental medicine and biology · 2023Article
- Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins.Aging and disease · 2022Article
- Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression.International journal of biological sciences · 2022Article
- Prostaglandin EStem cell reviews and reports · 2021Article
- Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice.Aging and disease · 2021Article
- B-Cell Regeneration Profile and Minimal Residual Disease Status in Bone Marrow of Treated Multiple Myeloma Patients.Cancers · 2021Article
- Vampires 2.0? The ethical quandaries of young blood infusion in the quest for eternal life.Medicine, health care, and philosophy · 2020Article
- Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling.Cytotechnology · 2018Article
- Updates on Old and Weary Haematopoiesis.International journal of molecular sciences · 2018Review
- A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.PLoS biology · 2018Article
- FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche.Experimental hematology · 2017Article
- Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.Experimental gerontology · 2017Review
- The epigenetic basis of hematopoietic stem cell aging.Seminars in hematology · 2017Review
- The Fountain of Youth: A Tale of Parabiosis, Stem Cells, and Rejuvenation.Open medicine (Warsaw, Poland) · 2017Article
- Immunosenescence of microglia and macrophages: impact on the ageing central nervous system.Brain : a journal of neurology · 2016Review
- Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells.Age (Dordrecht, Netherlands) · 2015Article
Corrections and comments
- Retraction · 2010-10-14Error in Data · Unreliable Data · Unreliable Results and/or Conclusions · · Shane Mayack has NIH finding of misconduct: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-147.html
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- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ageing in multicellular organisms typically involves a progressive decline in cell replacement and repair processes, resulting in several physiological deficiencies, including inefficient muscle repair, reduced bone mass, and dysregulation of blood formation (haematopoiesis). Although defects in tissue-resident stem cells clearly contribute to these phenotypes, it is unclear to what extent they reflect stem cell intrinsic alterations or age-related changes in the stem cell supportive microenvironment, or niche. Here, using complementary in vivo and in vitro heterochronic models, we show that age-associated changes in stem cell supportive niche cells deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction. Furthermore, we find that age-dependent defects in niche cells are systemically regulated and can be reversed by exposure to a young circulation or by neutralization of the conserved longevity regulator, insulin-like growth factor-1, in the marrow microenvironment. Together, these results show a new and critical role for local and systemic factors in signalling age-related haematopoietic decline, and highlight a new model in which blood-borne factors in aged animals act through local niche cells to induce age-dependent disruption of stem cell function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.