ArticleArteriosclerosis, thrombosis, and vascular biology2010
ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium.Scientific reports · 2018Pooled it
- Identification of key genes related to macrophages and metabolic reprogramming in myocardial infarct based on single-cell and bulk transcriptomics data and experimental validation.BMC cardiovascular disorders · 2026Article
- Review
- Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio associated with psoriasis: a cross-sectional study.Frontiers in medicine · 2024Article
- The role of caveolae in endothelial dysfunction.Medical review (2021) · 2021Article
- MicroRNA regulation of cholesterol metabolism.Annals of the New York Academy of Sciences · 2021Review
- The Roles of Lipoprotein in Psoriasis.International journal of molecular sciences · 2020Review
- ABCG1 Attenuates Oxidative Stress Induced by HAnalytical cellular pathology (Amsterdam) · 2020Article
- Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis.International journal of molecular sciences · 2018Review
- AIBP protects against metabolic abnormalities and atherosclerosis.Journal of lipid research · 2018Article
- Psoriasis-associated vascular disease: the role of HDL.Journal of biomedical science · 2017Review
- Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases.International journal of molecular sciences · 2017Review
- ABCG1 regulates pulmonary surfactant metabolism in mice and men.Journal of lipid research · 2017Article
- Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction.Journal of lipid research · 2015Article
- High-density lipoprotein: a novel target for antirestenosis therapy.Clinical and translational science · 2014Review
- Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease.EMBO molecular medicine · 2014Review
- A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.Journal of translational medicine · 2014Article
- Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.Scientific reports · 2014Article
- Cardioprotective functions of HDLs.Journal of lipid research · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveActivated endothelium and increased monocyte-endothelial interactions in the vessel wall are key early events in atherogenesis. ATP binding cassette (ABC) transporters play important roles in regulating sterol homeostasis in many cell types. Endothelial cells (EC) have a high capacity to efflux sterols and express the ABC transporter, ABCG1. Here, we define the role of ABCG1 in the regulation of lipid homeostasis and inflammation in aortic EC. METHODS AND
resultsUsing EC isolated from ABCG1-deficient mice (ABCG1 KO), we observed reduced cholesterol efflux to high-density lipoprotein compared to C57BL/6 (B6) EC. However, total cholesteryl ester levels were not changed in ABCG1 KO EC. Secretions of KC, MCP-1, and IL-6 by ABCG1 KO EC were significantly increased, and surface expressions of intercellular adhesion molecule-1 and E-selectin were increased several-fold on ABCG1 KO EC. Concomitant with these findings, we observed a 4-fold increase in monocyte adhesion to the intact aortic endothelium of ABCG1 KO mice ex vivo and to isolated aortic EC from these mice in vitro. In a gain-of-function study in vitro, restoration of ABCG1 expression in ABCG1 KO EC reduced monocyte-endothelial interactions. Utilizing pharmacological inhibitors for STAT3 and the IL-6 receptor, we found that blockade of STAT3 and IL-6 receptor signaling in ABCG1 KO EC completely abrogated monocyte adhesion to ABCG1 KO endothelium.
conclusionsABCG1 deficiency in aortic endothelial cells activates endothelial IL-6-IL-6 receptor-STAT3 signaling, thereby increasing monocyte-endothelial interactions and vascular inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.