ArticleClinical journal of the American Society of Nephrology : CJASN2010
Imprecision of creatinine-based GFR estimates in uninephric kidney donors.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- Time to Change Our Viewpoints to Assess Renal Risks in Patients with Solitary Kidneys beyond Traditional Approaches?Journal of clinical medicine · 2023Article
- Article
- A comparison of pre- and post-operative outcomes in living donors undergoing transperitoneal laparoscopic nephrectomy and open nephrectomy: a retrospective single-center study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Long-term prognosis after kidney donation: a propensity score matched comparison of living donors and non-donors from two population cohorts.European journal of epidemiology · 2020Article
- Current Management of Patients With Acquired Solitary Kidney.Kidney international reports · 2019Review
- Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay.Transplantation · 2018Article
- Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies.Clinical and experimental nephrology · 2018Article
- Incident CKD after Radical or Partial Nephrectomy.Journal of the American Society of Nephrology : JASN · 2018Article
- Observational
- Donation, Not Disease! A Multiple-Hit Hypothesis on Development of Post-Donation Kidney Disease.Current transplantation reports · 2017Review
- The consequences of chronic kidney disease mislabeling in living kidney donors.Mayo Clinic proceedings · 2014Article
- Precision of estimating equations for GFR in children with a solitary functioning kidney: the KIMONO study.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Comparison of estimating equations for the prediction of glomerular filtration rate in kidney donors before and after kidney donation.PloS one · 2013Article
- Clinical Assessment of Follow-Up Cystatin C-Based eGFR in Live Kidney Donors.Korean journal of urology · 2012Article
- Diabetes: hyperfiltration-a risk factor for nephropathy in T1DM?Nature reviews. Endocrinology · 2012Article
- Understanding the effects of chronic kidney disease on cardiovascular risk: are there lessons to be learnt from healthy kidney donors?Journal of human hypertension · 2012Review
- Early renal function decline in type 2 diabetes.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Kidney function, albuminuria and cardiovascular risk factors in post-operative living kidney donors: a single-center, cross-sectional study.Clinical and experimental nephrology · 2011Article
- Debate: PRO Position. Formal assessment of donor kidney function should be mandatory.American journal of nephrology · 2011Article
- Chronic hepatitis C and chronic kidney disease.Digestive diseases and sciences · 2010Article
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Authors and funding
7 authors at 4 institutions in 1 country.
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Abstract
BACKGROUND AND
objectivesTo ensure long-term safety of living kidney donors, it is now recommended that they be followed for at least 2 years after donation and that serum creatinine levels be monitored. Such levels are often subjected by clinical laboratories to estimating equations and are reported as estimated GFR (eGFR). The accuracy of such equations in uninephric living donors has yet to be validated. This is especially important in older living donors, who often have senescence-related depression of GFR. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We compared urinary creatinine clearance, four-variable Modification of Diet in Renal Disease estimating equation (eGFR), and the recently reported CKD-EPI GFR estimating equation with true GFR measured by the urinary iothalamate clearance (iGFR) in 64 subjects after kidney donation.
resultsCreatinine clearance overestimated iGFR. Both creatinine-based estimating equations were poorly correlated with and underestimated iGFR. More than half of kidney donors had eGFR <60 ml/min per 1.73 m(2) after donation, a level that categorized them as having stage 3 chronic kidney disease by our current laboratory reporting, whereas only 25% had iGFR <60 ml/min per 1.73 m(2). This misclassification disproportionately affected older donors age > or =55 years, of whom 80% had eGFR <60 ml/min per 1.73 m(2). Neither significant albuminuria nor hypertension was observed.
conclusionsThe current practice of reporting eGFR after donation commonly leads to a misclassification of chronic kidney disease, particularly in older donors. To ensure long-term well-being of living kidney donors, more precise estimates of GFR are required, particularly among older potential donors.
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