ArticleThe Journal of allergy and clinical immunology2010
Vaccinia virus-specific molecular signature in atopic dermatitis skin.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00407069 (Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus (ADVN AMP01)
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier.International journal of molecular sciences · 2021Review
- Immunological Roles of NLR in Allergic Diseases and Its Underlying Mechanisms.International journal of molecular sciences · 2021Review
- Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.Frontiers in immunology · 2020Review
- Effects of Allergic Sensitization on Antiviral Immunity: Allergen, Virus, and Host Cell Mechanisms.Current allergy and asthma reports · 2017Review
- Review
- Bacterial and Viral Infections in Atopic Dermatitis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair.The Journal of investigative dermatology · 2013Article
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.Human genetics · 2012Article
- Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?The Journal of allergy and clinical immunology · 2012Review
- Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.The Journal of investigative dermatology · 2012Article
- Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.Immunological reviews · 2011Review
- Article
- Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.The Journal of allergy and clinical immunology · 2011Article
- CD14, a key candidate gene associated with a specific immune response to cockroach.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
- The infectious aspects of atopic dermatitis.Immunology and allergy clinics of North America · 2010Review
- Skin barrier in atopic dermatitis: beyond filaggrin.Anais brasileiros de dermatologiaReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEczema vaccinatum (EV), a disseminated viral skin infection, is a life-threatening complication of vaccinia virus (VV) inoculation in patients with atopic dermatitis (AD) and is thought to be associated with a defective innate immune response. However, the precise mechanism or mechanisms and key factor or factors of EV are unknown.
objectiveGiven that patients with psoriasis, another inflammatory skin disorder, are not susceptible to EV, we compared the global transcriptional response of skin to VV in healthy subjects, patients with psoriasis, and patients with AD, focusing on AD-specific genes. We hypothesized that differences in the transcriptional response to VV between patients with AD and patients with psoriasis or healthy subjects would identify a defective pathway or pathways that might be associated with the development of EV.
methodsGene expression profiling of sham-treated and VV-treated unaffected skin explants from patients with AD (n = 12), patients with psoriasis (n = 12), or healthy subjects (n = 13) were generated with U133_Plus2 (54,613 probe sets) GeneChips and analyzed with the GCOS_1.4/SAM_2.1/MAPPFinder_2.0 pipeline.
resultsSixty-seven genes were significantly affected by VV in AD skin but not in psoriatic and healthy skin. Genes associated with defense response, response to wounding, and immune response were the most affected by VV in AD skin. All genes in these ontologies were downregulated, including the innate immunity genes leukotriene B(4) receptor (LTB4R), orosomucoid 1 (ORM1), coagulation factor II (thrombin) receptor (F2R), complement component 9 (C9), and LPS-binding protein (LBP). These findings were confirmed by means of real-time PCR and validated by means of PubMatrix analysis. ORM1, Toll-like receptor 4 (TLR4), and NLR family pyrin domain containing 1 (NLRP1) genes were also linked to AD severity.
conclusionThis study identified groups of innate immunity genes that are associated with the aberrant response of AD skin to VV and represent potential targets for EV pathogenesis.
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