Evidence map›Paper›PMID 20109729›Full record

ReviewThe Journal of allergy and clinical immunology2010

Recent insights into atopic dermatitis and implications for management of infectious complications.

Mark Boguniewicz, Donald Y M Leung

2 registry-linked trialsAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
35.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01597817 phase2completednot on this mapstarted 2011, after this paper: background citation

A Randomized Controlled Trial of the Efficacy and Safety of a a Biofunctional Textile in the Management of Atopic Dermatitis

TypeinterventionalSponsorUniversidade do PortoRan2011 to 2012Enrolled78ConditionsAtopic DermatitisArmschitosan coated textile, chitosan free cotton long sleeved t-shirts and pants.
NCT03018275 phase1 / phase2completednot on this mapstarted 2017, after this paper: background citation

Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis Phase I/II

TypeinterventionalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2017 to 2019Enrolled31ConditionsAtopic DermatitisArmsRoseomonas mucosa
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 332 citations in OpenAlex.

  1. Trial
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  6. Article
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  8. Review
  9. Article
  10. Atopic Dermatitis Disease Complications.Advances in experimental medicine and biology · 2024
    Article
  11. Article
  12. Microbiology spectrum · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Tralokinumab for the Treatment of Atopic Dermatitis.American journal of clinical dermatology · 2021
    Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark BoguniewiczDivision of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA. boguniewiczm@njhealth.org
Donald Y M Leung
National Jewish Health · USUniversity of Colorado Denver · US

Funding

Atopic Dermatitis and Vaccinia Immunization Network Clinical ConsortiumN01AI40029 · NIAID · NATIONAL JEWISH HEALTH · 2008 to 2010
$8.6M
THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASER01AR041256 · NIAMS · NATIONAL JEWISH HEALTH · PI GOLEVA, ELENA, LEUNG, DONALD YM · 1992 to 2020
$5.9M
ATOPIC DERMITITIS VACCINIA NETWORK /ADVN/-266040029N01AI040029 · NIAID · NATIONAL JEWISH MEDICAL AND RESEARCH CEN · PI LEUNG, DONALD YM · 2006 to 2006
–
NIAID NIH HHS HHSN266200400029CNIAID NIH HHS N01 AI040029NIAID NIH HHS N01 AI 40029NIAMS NIH HHS AR41256NIAMS NIH HHS R01 AR041256PHS HHS 40030
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.

Indexed as

Herpes SimplexSimplexvirusSkinStaphylococcal Skin InfectionsStaphylococcus aureusChild, PreschoolDermatitis, AtopicEpidermisHumans

Identifiers

PMID20109729
PMCPMC2814072
OpenAlexW2066989460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.