ArticleVirus research2010
Genomic characterization of human adenovirus 36, a putative obesity agent.
Article in Virus research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Liver Transaminases in Pediatric Adenovirus Infection-A Five-Year Study in Two Major Reference Centers from Romania.Microorganisms · 2023Article
- Long-term infection passaging of Human Adenovirus 36 in monkey kidney cells.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Presence of Adenovirus-36 DNA in Adipose Tissue of Women: Relationship with Adipocyte Morphology and the Expression of C/EBPβ and HIF-1α.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Genomics-based re-examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis.Cladistics : the international journal of the Willi Hennig Society · 2020Article
- A Murine Monoclonal Antibody With Potent Neutralization Ability Against Human Adenovirus 7.Frontiers in cellular and infection microbiology · 2019Article
- Adenoviromics: Mining the Human Adenovirus Species D Genome.Frontiers in microbiology · 2018Review
- Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?International journal of obesity (2005) · 2016Article
- The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity.International journal of chronic diseases · 2016Review
- Adenovirus 36 and Obesity: An Overview.Viruses · 2015Review
- High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries.Virology journal · 2014Article
- Genomic stability of adipogenic human adenovirus 36.International journal of obesity (2005) · 2014Article
- Article
- Beyond fast food and slow motion: weighty contributors to the obesity epidemic.Journal of endocrinological investigation · 2012Review
- Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA.PloS one · 2012Article
- Molecular evolution of human species D adenoviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Infectivity period of mice inoculated with human adenoviruses.Laboratory animals · 2011Article
- Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality.Virology · 2011Article
- The revolution in viral genomics as exemplified by the bioinformatic analysis of human adenoviruses.Viruses · 2010Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
Increased levels of serum antibody titers against human adenovirus 36 (HAdV-D36) are associated with human obesity and experimental obesity in laboratory animals. While HAdV-D36 has been studied as an infectious agent implicated in obesity for over a decade, the complete genome sequence and its analysis have yet to be reported. A detailed analysis of the genome sequence of HAdV-D36 may be important to understand its role in obesity. Genomic and bioinformatic comparisons with other HAdVs identified differences that suggested unique functions. Global pairwise genome alignment with all sequenced human adenovirus D (HAdV-D) genomes revealed areas of nonconserved sequences in the hexon, E3 CR1 beta, E3 CR1 gamma, and fiber genes. Phylogenetic analysis of all HAdV-D36 proteins confirmed that this virus belongs to species Human adenovirus D. This genomic analysis of HAdV-D36 provides an important tool for comprehending the role that this unique adenovirus may play in human obesity. Low amino acid sequence identity in the E3 CR1 beta and CR1 gamma genes may suggest distinctive roles for these proteins. Furthermore, the predicted molecular models of the HAdV-D36 fiber protein seem to implicate a unique tissue tropism for HAdV-D36.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.