ArticleBMC genetics2010
Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Mitochondria: The Retina's Achilles' Heel in AMD.Advances in experimental medicine and biology · 2021Article
- Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2018Article
- Bioinformatics Tools and Databases to Assess the Pathogenicity of Mitochondrial DNA Variants in the Field of Next Generation Sequencing.Frontiers in genetics · 2018Review
- Article
- Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study.BMC medical genetics · 2013Article
- Article
- Mitochondrial genetic background plays a role in increasing risk to asthma.Molecular biology reports · 2012Article
- Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients.Molecular vision · 2011Article
- Mitochondrial disorders and the eye.Eye and brain · 2011Review
- Genetics and genomics of pseudoexfoliation syndrome/glaucoma.Middle East African journal of ophthalmology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious lines of evidence demonstrate the involvement of mitochondrial dysfunction in the pathogenesis of glaucoma. Therefore, mitochondrial DNA is a promising candidate for genetic susceptibility studies on glaucoma. To test the hypothesis that mitochondrial haplogroups influence the risk to develop glaucoma, we genotyped 12 single-nucleotide polymorphisms that define the European mitochondrial DNA haplogroups in healthy controls and two German patient cohorts with either exfoliation glaucoma or the normal tension subgroup of primary open angle glaucoma.
resultsMitochondrial haplogroup U was significantly under-represented in patients with exfoliation glaucoma (8.3% compared with 18.9% in controls; p = 0.004).
conclusionsPeople with haplogroup U have a lower risk to develop exfoliation glaucoma. Our results substantiate the suggestion that mitochondrial alterations have an impact on the etiology of glaucoma.
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