ArticleOrganic letters2010
N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA.
Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach.Molecules (Basel, Switzerland) · 2020Review
- Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry.ACS chemical biology · 2019Article
- Practical synthesis ofMonatshefte fur chemie · 2019Article
- TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length.Bioorganic & medicinal chemistry · 2018Article
- Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.Nature structural & molecular biology · 2016Article
- Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA.Bioorganic & medicinal chemistry letters · 2016Article
- Base modification strategies to modulate immune stimulation by an siRNA.Chembiochem : a European journal of chemical biology · 2015Article
- Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2.Nucleic acids research · 2015Article
- Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA.ACS chemical biology · 2014Article
- Short interfering RNA guide strand modifiers from computational screening.Journal of the American Chemical Society · 2013Article
- Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.Molecules (Basel, Switzerland) · 2012Review
- 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove.Organic & biomolecular chemistry · 2012Article
- Enzymatic incorporation of an azide-modified UTP analog into oligoribonucleotides for post-transcriptional chemical functionalization.Nature protocols · 2012Article
- N-activated β-lactams as versatile reagents for acyl carrier protein labeling.Organic & biomolecular chemistry · 2012Article
- Novel modifications in RNA.ACS chemical biology · 2012Review
- Chemical modification of siRNA bases to probe and enhance RNA interference.The Journal of organic chemistry · 2011Review
- Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.Journal of the American Chemical Society · 2011Article
- 8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.Journal of the American Chemical Society · 2011Article
- Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs.ACS chemical biology · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Nucleoside analogs that project substituents into the minor groove when incorporated into duplex RNA perturb the binding of proteins and can affect base pairing specificity. The synthesis of 2-aminopurine ribonucleoside analogs and their phosphoramidites, their incorporation into duplex RNA, their postsynthetic modification via Cu-catalyzed azide-alkyne cycloaddition (CuAAC), and their effect on duplex stability and base pairing specificity are described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.