ArticleBiomacromolecules2010
Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery.
Article in Biomacromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Functional Self-Immolative Hydrogels with Dendritic Cross-Linkers for Controlled Drug Delivery.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Recent Research Progress on Polyamidoamine-Engineered Hydrogels for Biomedical Applications.Biomolecules · 2024Review
- Dendrimer and dendrimer gel-derived drug delivery systems: Breaking bottlenecks of topical administration of glaucoma medications.MedComm - biomaterials and applications · 2023Article
- Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution.Pharmaceutics · 2023Review
- Dendrimer-based drug delivery systems: history, challenges, and latest developments.Journal of biological engineering · 2022Review
- Recent Advances in Polymer Additive Engineering for Diagnostic and Therapeutic Hydrogels.International journal of molecular sciences · 2022Review
- Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications.Chemical reviews · 2020Review
- Drug-Conjugated Dendrimer Hydrogel Enables Sustained Drug Release via a Self-Cleaving Mechanism.Molecular pharmaceutics · 2019Article
- Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction.Scientific reports · 2018Article
- Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery.ACS biomaterials science & engineering · 2017Article
- In Situ-Forming Polyamidoamine Dendrimer Hydrogels with Tunable Properties Prepared via Aza-Michael Addition Reaction.ACS applied materials & interfaces · 2017Article
- Dendrimers and Dendrons as Versatile Building Blocks for the Fabrication of Functional Hydrogels.Molecules (Basel, Switzerland) · 2016Review
- Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers.Molecules (Basel, Switzerland) · 2016Article
- Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications.Nanomaterials (Basel, Switzerland) · 2015Review
- Electrospinning of PEGylated polyamidoamine dendrimer fibers.Materials science & engineering. C, Materials for biological applications · 2015Article
- The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application.Biomaterials science · 2015Article
- Semi-interpenetrating network (sIPN) co-electrospun gelatin/insulin fiber formulation for transbuccal insulin delivery.Pharmaceutical research · 2015Article
- 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties.Biomacromolecules · 2013Article
- Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation.Molecular pharmaceutics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this work, we describe a novel polyamidoamine (PAMAM) dendrimer hydrogel (DH) platform with potential for tissue engineering and drug delivery. With PAMAM dendrimer G3.0 being the underlying carrier, polyethylene glycol (PEG) chains of various lengths (MW = 1500, 6000, or 12000 g mol(-1)) were coupled to the dendrimer to different extents, and the resulting PEGylated PAMAM dendrimers were further coupled with acrylate groups to yield photoreactive dendrimer macromonomers for gel formation. It was found that gelation based on photoreactive PAMAM G3.0 macromonomers was restricted by the degree of PEGylation, PEG chain length, and the distribution of acrylate groups on the dendrimer surface. Further, the architecture of the photoreactive macromonomers affects the structural stability and swelling of the resultant networks. A completely cross-linked network (DH-G3.0-12000(H)) with a high water swelling ratio was created by UV-curing of PAMAM dendrimer G3.0 coupled with 28 PEG 12000 chains in the presence of the eosin Y-based photoinitiating system. The disintegration of DH-G3.0-12000(H) was pH-insensitive. DH-G3.0-12000(H) was found to have similar cytocompatibility to un-cross-linked G3.0-12000(H) but a significantly lower cellular uptake by macrophages. With PAMAM dendrimer G3.5 being the underlying carrier, the dendrimer modified with 43 PEG 1500 chains was able to form a completely cross-linked network (DH-G3.5-1500(H)) by UV-curing in the presence of the eosin Y-based photoinitiating system. DH-G3.5-1500(H) exhibited pH-dependent disintegration. Its disintegration ratio increased with pH. PAMAM dendrimer hydrogels uniquely express the structural characteristics of both PEG hydrogel and PAMAM dendrimer and have potential for various applications in tissue engineering and drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.