ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Groucho co-repressor proteins regulate β cell development and proliferation by repressingDevelopment (Cambridge, England) · 2021Article
- Differential Regulation ofCells · 2019Article
- Article
- Orchestrating liver development.Development (Cambridge, England) · 2015Review
- PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.Stem cell reports · 2015Article
- Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.Diabetes · 2014Article
- A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.Journal of proteome research · 2013Article
- Forkhead box proteins: tuning forks for transcriptional harmony.Nature reviews. Cancer · 2013Review
- Cellular and molecular basis of liver development.Comprehensive Physiology · 2013Review
- Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.Developmental biology · 2013Article
- The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.Development (Cambridge, England) · 2012Article
- Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.Nucleus (Austin, Tex.) · 2012Review
- Pioneer transcription factors: establishing competence for gene expression.Genes & development · 2011Review
- Restriction of hepatic competence by Fgf signaling.Development (Cambridge, England) · 2011Article
- Pioneer factors in embryonic stem cells and differentiation.Current opinion in genetics & development · 2010Review
- The FoxA factors in organogenesis and differentiation.Current opinion in genetics & development · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
While much is known about Groucho corepressors in Drosophila development, less is known about Grg homologs in mammalian embryogenesis. The transcription factors FoxA1 and FoxA2 are redundantly necessary for liver-inductive competence of the endoderm, and recently we found that FoxA factors bind Grg3, recruit the corepressor to FoxA target genes, and cause transcriptional repression, when Grg3 is ectopically expressed in adult liver cell lines that express little or no endogenous Grg. Unexpectedly, we now find that Grg1 and Grg3 mRNAs are co-expressed with FoxA factors in the foregut endoderm, prior to liver differentiation, though only Grg3 protein is expressed there. Grg3 mRNA and protein are extinguished at the onset of liver differentiation. Lentiviral delivery of Grg3 to explants of foregut endoderm suppresses liver gene induction. We suggest that Grg expression in the endoderm helps suppress the liver program and find that endodermal competence involves a balance between activators and corepressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.