Evidence map›Paper›PMID 20108126›Full record

ArticleJournal of general internal medicine2010

Comorbid depression is associated with an increased risk of dementia diagnosis in patients with diabetes: a prospective cohort study.

Wayne J Katon, Elizabeth H B Lin, Lisa H Williams, Paul Ciechanowski, Susan R Heckbert, Evette Ludman, Carolyn Rutter, Paul K Crane, Malia Oliver, Michael Von Korff

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of general internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wayne J KatonDepartment of Psychiatry & Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560, Seattle, WA 98195-6560, USA. wkaton@u.washington.edu
Elizabeth H B Lin
Lisa H Williams
Paul Ciechanowski
Susan R Heckbert
Evette Ludman
Carolyn Rutter
Paul K Crane
Malia Oliver
Michael Von Korff
Kaiser Permanente Washington Health Research Institute · USUniversity of Washington · USVA Puget Sound Health Care System · US

Funding

Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Depression-Diabetes Care Disparities, Adverse OutcomesR01MH073686 · NIMH · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI VON KORFF, MICHAEL R · 2005 to 2008
$1.8M
Quality Improvement of School Mental Health ServicesK08MH069741 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KATAOKA, SHERYL H · 2004 to 2008
$769k
NIA NIH HHS U01 AG006781NIMH NIH HHS K08 MH069741NIMH NIH HHS K24 MH069741NIMH NIH HHS R01 MH073686
6 · The paper itself

Abstract

backgroundBoth depression and diabetes have been found to be risk factors for dementia. This study examined whether comorbid depression in patients with diabetes increases the risk for dementia compared to those with diabetes alone.

methodsWe conducted a prospective cohort study of 3,837 primary care patients with diabetes (mean age 63.2 +/- 13.2 years) enrolled in an HMO in Washington State. The Patient Health Questionnaire (PHQ-9) was used to assess depression at baseline, and ICD-9 diagnoses for dementia were used to identify cases of dementia. Cohort members with no previous ICD-9 diagnosis of dementia prior to baseline were followed for a 5-year period. The risk of dementia for patients with both major depression and diabetes at baseline relative to patients with diabetes alone was estimated using cause-specific Cox proportional hazard regression models that adjusted for age, gender, education, race/ethnicity, diabetes duration, treatment with insulin, diabetes complications, nondiabetes-related medical comorbidity, hypertension, BMI, physical inactivity, smoking, HbA(1c), and number of primary care visits per month.

resultsOver the 5-year period, 36 of 455 (7.9%) patients with major depression and diabetes (incidence rate of 21.5 per 1,000 person-years) versus 163 of 3,382 (4.8%) patients with diabetes alone (incidence rate of 11.8 per 1,000 person-years) had one or more ICD-9 diagnoses of dementia. Patients with comorbid major depression had an increased risk of dementia (fully adjusted hazard ratio 2.69, 95% CI 1.77, 4.07).

conclusionsPatients with major depression and diabetes had an increased risk of development of dementia compared to those with diabetes alone. These data add to recent findings showing that depression was associated with an increased risk of macrovascular and microvascular complications in patients with diabetes.

Indexed as

AgedCohort StudiesComorbidityDementiaDiabetes ComplicationsDiabetes MellitusFemaleFollow-Up StudiesHumansMajor Depressive DisorderMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID20108126
PMCPMC2855007
OpenAlexW1993541562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.