ArticlePLoS genetics2010
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 111 citations in OpenAlex.
- Article
- Tubulin Acetylation: A Critical Regulator of Microtubule Function.Results and problems in cell differentiation · 2025Review
- Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people's tax dollars.Ageing research reviews · 2024Review
- MEC-12/alpha tubulin regulates mitochondrial distribution and mitophagy during oxidative stress inmicroPublication biology · 2024Article
- Rescue of a familial dysautonomia mouse model by AAV9-Exon-specific U1 snRNA.American journal of human genetics · 2022Article
- Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage.Journal of genetics and genomics = Yi chuan xue bao · 2022Article
- Selective retinal ganglion cell loss and optic neuropathy in a humanized mouse model of familial dysautonomia.Human molecular genetics · 2022Article
- Elongator promotes neuritogenesisFrontiers in cell and developmental biology · 2022Article
- ATP-citrate lyase promotes axonal transport across species.Nature communications · 2021Article
- Role of tubulin acetylation in cellular functions and diseases.Medical molecular morphology · 2020Review
- Plant Elongator-Protein Complex of Diverse Activities Regulates Growth, Development, and Immune Responses.International journal of molecular sciences · 2020Review
- Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum.Nucleic acids research · 2020Article
- Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide.Scientific reports · 2020Article
- Retrograde nerve growth factor signaling abnormalities in familial dysautonomia.The Journal of clinical investigation · 2020Article
- Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development.International journal of molecular sciences · 2020Article
- Alanine tRNAs Translate Environment Into Behavior inFrontiers in cell and developmental biology · 2020Article
- ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation.Cellular and molecular life sciences : CMLS · 2019Article
- Forward Genetic Screen forG3 (Bethesda, Md.) · 2019Article
- Emerging Role of Sirtuin 2 in Parkinson's Disease.Frontiers in aging neuroscience · 2019Review
- Structural insights into the function of Elongator.Cellular and molecular life sciences : CMLS · 2018Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Although acetylated alpha-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate alpha-tubulin acetylation are, to date, largely unknown. Therefore, a genetic screen was employed in the nematode Caenorhabditis elegans that identified the Elongator complex as a possible regulator of alpha-tubulin acetylation. Detailed characterization of mutant animals revealed that the acetyltransferase activity of the Elongator is indeed required for correct acetylation of microtubules and for neuronal development. Moreover, the velocity of vesicles on microtubules was affected by mutations in Elongator. Elongator mutants also displayed defects in neurotransmitter levels. Furthermore, acetylation of alpha-tubulin was shown to act as a novel signal for the fine-tuning of microtubules dynamics by modulating alpha-tubulin turnover, which in turn affected neuronal shape. Given that mutations in the acetyltransferase subunit of the Elongator (Elp3) and in a scaffold subunit (Elp1) have previously been linked to human neurodegenerative diseases, namely Amyotrophic Lateral Sclerosis and Familial Dysautonomia respectively highlights the importance of this work and offers new insights to understand their etiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.