ArticleJournal of neurophysiology2010
Response latency to lingual taste stimulation distinguishes neuron types within the geniculate ganglion.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Computational Advances in Taste Perception: From Ion Channels and Taste Receptors to Neural Coding.Brain sciences · 2025Article
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Oral thermal processing in the gustatory cortex of awake mice.Chemical senses · 2023Article
- Analysis of the rat chorda tympani nerve response to "super salty" sodium carbonate.Chemical senses · 2023Article
- The Neural Code for Taste in the Nucleus of the Solitary Tract of Rats with Obesity Following Roux-En-Y Gastric Bypass Surgery.Nutrients · 2022Article
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- Variable Branching Characteristics of Peripheral Taste Neurons Indicates Differential Convergence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Variation in taste ganglion neuron morphology: insights into taste function and plasticity.Current opinion in physiology · 2021Article
- Enhancing GABAergic Tone in the Rostral Nucleus of the Solitary Tract Reconfigures Sensorimotor Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Optogenetic Stimulation of Type I GAD65The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Cortical processing of chemosensory and hedonic features of taste in active licking mice.Journal of neurophysiology · 2020Article
- Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double-knockout mice.Journal of neurophysiology · 2020Article
- Taste Responses in the Nucleus of the Solitary Tract of Awake Obese Rats Are Blunted Compared With Those in Lean Rats.Frontiers in integrative neuroscience · 2019Article
- A computational analysis of signal fidelity in the rostral nucleus of the solitary tract.Journal of neurophysiology · 2018Article
- Salivary proteins alter taste-guided behaviors and taste nerve signaling in rat.Physiology & behavior · 2018Article
- Thirst Increases Chorda Tympani Responses to Sodium Chloride.Chemical senses · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to investigate the role of response latency in discrimination of chemical stimuli by geniculate ganglion neurons in the rat. Accordingly, we recorded single-cell 5-s responses from geniculate ganglion neurons (n = 47) simultaneously with stimulus-evoked summated potentials (electrogustogram; EGG) from the anterior tongue to signal when the stimulus contacted the lingual epithelium. Artificial saliva served as the rinse solution and solvent for all stimuli [(0.5 M sucrose, 0.03-0.5 M NaCl, 0.01 M citric acid, and 0.02 M quinine hydrochloride (QHCl)], 0.1 M KCl as well as for 0.1 M NaCl +1 μM benzamil. Cluster analysis separated neurons into four groups (sucrose specialists, NaCl specialists, NaCl/QHCl generalists and acid generalists). Artificial saliva elevated spontaneous firing rate and response frequency of all neurons. As a rule, geniculate ganglion neurons responded with the highest frequency and shortest latency to their best stimulus with acid generalist the only exception. For specialist neurons and NaCl/QHCl generalists, the average response latency to the best stimulus was two to four times shorter than the latency to secondary stimuli. For NaCl-specialist neurons, response frequency increased and response latency decreased systematically with increasing NaCl concentration; benzamil significantly decreased NaCl response frequency and increased response latency. Acid-generalist neurons had the highest spontaneous firing rate and were the only group that responded consistently to citric acid and KCl. For many acid generalists, a citric-acid-evoked inhibition preceded robust excitation. We conclude that response latency may be an informative coding signal for peripheral chemosensory neurons.
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