ArticleDiabetes2010
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The crucial role and mechanism of insulin resistance in metabolic disease.Frontiers in endocrinology · 2023Pooled it
- Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.Nutrition journal · 2022Pooled it
- Interventions outside the workplace for reducing sedentary behaviour in adults under 60 years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis.PloS one · 2016Pooled it
- Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis.Diabetologia · 2012Pooled it
- Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.EBioMedicine · 2018Trial
- Association of TCF7L2 and LEPR gene variants (rs7903146 and rs1137101) with primary knee osteoarthritis in a northern Mexican Mestizo population.Clinical rheumatology · 2026Article
- Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.Diabetes, obesity & metabolism · 2025Article
- The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults.Scientific reports · 2022Article
- Pharmacogenetics of posttransplant diabetes mellitus.The pharmacogenomics journal · 2017Review
- Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia.Endocrine connections · 2016Article
- Novel phenotypes of prediabetes?Diabetologia · 2016Review
- TCF7L2 polymorphism is associated with low nitric oxide release, endothelial dysfunction and enhanced inflammatory response after myocardial infarction.BBA clinical · 2016Article
- Relationship Between Sedentary Behavior and Cardiovascular Risk.Current cardiology reports · 2016Review
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- The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective.Cell & bioscience · 2012Article
- Acute sedentary behaviour and markers of cardiometabolic risk: a systematic review of intervention studies.Journal of nutrition and metabolism · 2012Article
- The role of the Wnt signaling pathway in incretin hormone production and function.Frontiers in physiology · 2012Article
- Ten questions about systems biology.The Journal of physiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest. RESEARCH DESIGN AND
methodsA total of 38 healthy young Caucasian men were studied before and after bed rest using the hyperinsulinemic-euglycemic clamp technique combined with indirect calorimetry preceded by an intravenous glucose tolerance test. The TCF7L2 rs7903146 was genotyped using allelic discrimination performed with an ABI 7900 system. The genetic analyses were done assuming a dominant model of inheritance.
resultsThe first-phase insulin response (FPIR) was significantly lower in carriers of the T-allele compared with carriers of the CC genotype before bed rest, with and without correction for insulin resistance. The incremental rise of FPIR in response to insulin resistance induced by bed rest was lower in carriers of the T-allele (P < 0.001). Fasting plasma glucagon levels were significantly lower in carriers of the T-allele before and after bed rest. While carriers of the CC genotype developed increased hepatic insulin resistance, the TCF7L2 rs7903146 did not influence peripheral insulin action or the rate of lipolysis before or after bed rest.
conclusionsHealthy carriers of the T-allele of TCF7L2 rs7903146 exhibit a diminished increase of insulin secretion in response to intravenous glucose to compensate for insulin resistance as induced by bed rest. Reduced paracrine glucagon stimulation may contribute to the impairment of beta-cell function in the carriers TCF7L2 rs7903146 T-allele associated with increased risk of type 2 diabetes.
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