ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 97 citations in OpenAlex.
- Piezo1 in intestinal smooth muscle cells: Emerging perspectives.The Journal of physiology · 2026Review
- Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel.Communications biology · 2025Article
- Exploring the diversity of biological processes regulated by glial cell line-derived neurotrophic factor, a pleiotropic molecule with therapeutic potential.Frontiers in physiology · 2025Review
- Altered Esophageal Smooth Muscle Phenotype in Achalasia.Journal of neurogastroenterology and motility · 2024Article
- Differences in enteric neuronal density in the NSE-Noggin mouse model across institutes.Scientific reports · 2024Article
- Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.eLife · 2023Article
- KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.Human genetics · 2023Article
- A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System.International journal of molecular sciences · 2022Article
- Overexpression of microRNA-211 in Functional Dyspepsia via Downregulation of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) by Increasing Phosphorylation of p38 MAPK Pathway.Canadian journal of gastroenterology & hepatology · 2022Article
- Development, Diversity, and Neurogenic Capacity of Enteric Glia.Frontiers in cell and developmental biology · 2021Review
- The Pivotal Role of Microbiota in Modulating the Neuronal-Glial-Epithelial Unit.Infection and drug resistance · 2021Review
- Review
- Semaphorin 3A controls enteric neuron connectivity and is inversely associated with synapsin 1 expression in Hirschsprung disease.Scientific reports · 2020Article
- Glial ACells · 2020Article
- Dlx1/2 mice have abnormal enteric nervous system function.JCI insight · 2020Article
- Molecular Mechanisms Underlying How Sialyllactose Intervention Promotes Intestinal Maturity by Upregulating GDNF Through a CREB-Dependent Pathway in Neonatal Piglets.Molecular neurobiology · 2019Article
- Down syndrome mouse models have an abnormal enteric nervous system.JCI insight · 2019Article
- Enteric nervous system development: what could possibly go wrong?Nature reviews. Neuroscience · 2018Review
- Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.ACS medicinal chemistry letters · 2018Article
- Development of interstitial cells of Cajal in the human digestive tract as the result of reciprocal induction of mesenchymal and neural crest cells.Journal of cellular and molecular medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret activation promotes ENS precursor survival, proliferation, and migration and provides trophic support for mature enteric neurons. Although these roles are well established, we now provide evidence that increasing levels of the Ret ligand glial cell line-derived neurotrophic factor (GDNF) in mice causes alterations in ENS structure and function that are critically dependent on the time and location of increased GDNF availability. This is demonstrated using two different strains of transgenic mice and by injecting newborn mice with GDNF. Furthermore, because different subclasses of ENS precursors withdraw from the cell cycle at different times during development, increases in GDNF at specific times alter the ratio of neuronal subclasses in the mature ENS. In addition, we confirm that esophageal neurons are GDNF responsive and demonstrate that the location of GDNF production influences neuronal process projection for NADPH diaphorase-expressing, but not acetylcholinesterase-, choline acetyltransferase-, or tryptophan hydroxylase-expressing, small bowel myenteric neurons. We further demonstrate that changes in GDNF availability influence intestinal function in vitro and in vivo. Thus, changes in GDNF expression can create a wide variety of alterations in ENS structure and function and may in part contribute to human motility disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.