ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Quantal analysis reveals a functional correlation between presynaptic and postsynaptic efficacy in excitatory connections from rat neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Longitudinal and Noninvasive Intracellular Recordings of Spontaneous Electrophysiological Activity in Rat Primary Neurons on Planar MEA Electrodes.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Average miniature post-synaptic potential size is inversely proportional to membrane capacitance across neocortical pyramidal neurons of different sizes.Frontiers in cellular neuroscience · 2025Article
- Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala.Nature neuroscience · 2024Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder.Frontiers in human neuroscience · 2023Article
- Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission.Frontiers in computational neuroscience · 2022Article
- Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma.eLife · 2021Article
- Structure and function of a neocortical synapse.Nature · 2021Article
- The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases.International journal of molecular sciences · 2020Review
- Neuronal Activity and Its Role in Controlling Antioxidant Genes.International journal of molecular sciences · 2020Review
- A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons.Nature biomedical engineering · 2020Article
- Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.Frontiers in synaptic neuroscience · 2020Review
- Parsing Out the Variability of Transmission at Central Synapses Using Optical Quantal Analysis.Frontiers in synaptic neuroscience · 2019Article
- Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex.Frontiers in synaptic neuroscience · 2019Article
- Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder.Frontiers in computational neuroscience · 2019Article
- The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.Cell reports · 2018Article
- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
- Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs.Trends in neurosciences · 2016Review
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6 authors.
Funding
Abstract
At many central synapses, the presynaptic bouton and postsynaptic density are structurally correlated. However, it is unknown whether this correlation extends to the functional properties of the synapses. To investigate this, we made recordings from synaptically coupled pairs of pyramidal neurons in rat visual cortex. The mean peak amplitude of EPSPs recorded from pairs of L2/3 neurons ranged between 40 microV and 2.9 mV. EPSP rise times were consistent with the majority of the synapses being located on basal dendrites; this was confirmed by full anatomical reconstructions of a subset of connected pairs. Over a third of the connections could be described using a quantal model that assumed simple binomial statistics. Release probability (P(r)) and quantal size (Q), as measured at the somatic recording site, showed considerable heterogeneity between connections. However, across the population of connections, values of P(r) and Q for individual connections were positively correlated with one another. This correlation also held for inputs to layer 5 pyramidal neurons from both layer 2/3 and neighboring layer 5 pyramidal neurons, suggesting that during development of cortical connections presynaptic and postsynaptic strengths are dependently scaled. For 2/3 to 2/3 connections, mean EPSP amplitude was correlated with both Q and P(r) values but uncorrelated with N, the number of functional release sites mediating the connection. The efficacy of a cortical connection is thus set by coordinated presynaptic and postsynaptic strength.
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