ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Presynaptic Trafficking of Glutamate Decarboxylase Isoforms Is Dispensable for Basal GABAergic Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator.Neurochemical research · 2025Review
- Glial Glutamine Homeostasis in Health and Disease.Neurochemical research · 2023Review
- Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy.Neuropharmacology · 2023Article
- DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.Cell reports · 2022Article
- Real-time imaging of glutamate transients in the extracellular space of acute human brain slices using a single-wavelength glutamate fluorescence nanosensor.Scientific reports · 2022Article
- Physiological synaptic activity and recognition memory require astroglial glutamine.Nature communications · 2022Article
- SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells.Frontiers in cell and developmental biology · 2022Article
- Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.International journal of molecular sciences · 2021Article
- D-Serine Signaling and NMDAR-Mediated Synaptic Plasticity Are Regulated by System A-Type of Glutamine/D-Serine Dual Transporters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation.Molecular neurobiology · 2020Review
- The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction.Brain : a journal of neurology · 2019Article
- Astrocytic glycogen metabolism in the healthy and diseased brain.The Journal of biological chemistry · 2018Review
- Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate.BioMed research international · 2018Review
- Acute Exposure to Pacific Ciguatoxin Reduces Electroencephalogram Activity and Disrupts Neurotransmitter Metabolic Pathways in Motor Cortex.Molecular neurobiology · 2017Article
- Functional identification of activity-regulated, high-affinity glutamine transport in hippocampal neurons inhibited by riluzole.Journal of neurochemistry · 2017Article
- Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy.Neurochemical research · 2017Review
- Article
- Disinhibition reduces extracellular glutamine and elevates extracellular glutamate in rat hippocampus in vivo.Epilepsy research · 2015Article
- Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The neurotransmitter glutamate is recycled through an astrocytic-neuronal glutamate-glutamine cycle in which synaptic glutamate is taken up by astrocytes, metabolized to glutamine, and transferred to neurons for conversion back to glutamate and subsequent release. The extent to which neuronal glutamate release is dependent upon this pathway remains unclear. Here we provide electrophysiological and biochemical evidence that in acutely disinhibited rat neocortical slices, robust release of glutamate during sustained epileptiform activity requires that neurons be provided a continuous source of glutamine. We demonstrate that the uptake of glutamine into neurons for synthesis of glutamate destined for synaptic release is not strongly dependent on the system A transporters, but requires another unidentified glutamine transporter or transporters. Finally, we find that the attenuation of network activity through inhibition of neuronal glutamine transport is associated with reduced frequency and amplitude of spontaneous events detected at the single-cell level. These results indicate that availability of glutamine influences neuronal release of glutamate during periods of intense network activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.