ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
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- Cellular Pathogenesis of Chemotherapy-Induced Peripheral Neuropathy: Insights FromFrontiers in pain research (Lausanne, Switzerland) · 2022Review
- Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes.Scientific reports · 2019Article
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- Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins.PloS one · 2015Article
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- Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors.Journal of neurophysiology · 2013Article
- A role for the cytoplasmic DEAD box helicase Dbp21E2 in rhodopsin maturation and photoreceptor viability.Journal of neurogenetics · 2012Article
- PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.Journal of neurogenetics · 2012Review
- A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Genome-wide profiling of diel and circadian gene expression in the malaria vector Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Light-dependent phosphorylation of the drosophila transient receptor potential ion channel.The Journal of biological chemistry · 2010Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Photoreceptor cells achieve high sensitivity, reliably detecting single photons, while limiting the spontaneous activation events responsible for dark noise. We used proteomic, genetic, and electrophysiological approaches to characterize Retinophilin (RTP) (CG10233) in Drosophila photoreceptors and establish its involvement in dark-noise suppression. RTP possesses membrane occupation and recognition nexus (MORN) motifs, a structure shared with mammalian junctophilins and other membrane-associated proteins found within excitable cells. We show the MORN repeats, and both the N- and C-terminal domains, are required for RTP localization in the microvillar light-gathering organelle, the rhabdomere. RTP exists in multiple phosphorylated isoforms under dark conditions and is dephosphorylated by light exposure. An RTP deletion mutant exhibits a high rate of spontaneous membrane depolarization events in dark conditions but retains the normal kinetics of the light response. Photoreceptors lacking neither inactivation nor afterpotential C (NINAC) myosin III, a motor protein/kinase, also display a similar dark-noise phenotype as the RTP deletion. We show that NINAC mutants are depleted for RTP. These results suggest the increase in dark noise in NINAC mutants is attributable to lack of RTP and, furthermore, defines a novel role for NINAC in the rhabdomere. We propose that RTP is a light-regulated phosphoprotein that organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors.
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