Evidence map›Paper›PMID 20106993›Full record

ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2010

Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure.

Alicia A McDonough

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 107 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The Renin-Angiotensin and Renal Dopaminergic Systems Interact in Normotensive Humans.Journal of the American Society of Nephrology : JASN · 2016
    Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
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  12. A key role of ATAmerican journal of physiology. Renal physiology · 2025
    Article
  13. Review
  14. The salt sensitivity of Drd4-null mice is associated with the upregulations of sodium transporters in kidneys.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. High dietary KAmerican journal of physiology. Renal physiology · 2023
    Article
  19. Article
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alicia A McDonoughDepartment of Cell and Neurobiology, University of Southern California, Los Angeles, California 90089-9142, USA. mcdonoug@usc.edu
University of Southern California · US

Funding

REGULATION ON SODIUM PUMPS IN THE KIDNEYR01DK034316 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCDONOUGH, ALICIA A. · 1986 to 2008
$2.7M
Regulation of Na-CI cotransporter (NCC) subcellular distribution in DCTR21HL085388 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCDONOUGH, ALICIA A. · 2006 to 2007
$402k
NHLBI NIH HHS HL-085388NHLBI NIH HHS R21 HL085388NIDDK NIH HHS DK-34316NIDDK NIH HHS R01 DK034316
6 · The paper itself

Abstract

One-hundred years ago, Starling articulated the interdependence of renal control of circulating blood volume and effective cardiac performance. During the past 25 years, the molecular mechanisms responsible for the interdependence of blood pressure (BP), extracellular fluid volume (ECFV), the renin-angiotensin system (RAS), and sympathetic nervous system (SNS) have begun to be revealed. These variables all converge on regulation of renal proximal tubule (PT) sodium transport. The PT reabsorbs two-thirds of the filtered Na(+) and volume at baseline. This fraction is decreased when BP or perfusion pressure is increased, during a high-salt diet (elevated ECFV), and during inhibition of the production of ANG II; conversely, this fraction is increased by ANG II, SNS activation, and a low-salt diet. These variables all regulate the distribution of the Na(+)/H(+) exchanger isoform 3 (NHE3) and the Na(+)-phosphate cotransporter (NaPi2), along the apical microvilli of the PT. Natriuretic stimuli provoke the dynamic redistribution of these transporters along with associated regulators, molecular motors, and cytoskeleton-associated proteins to the base of the microvilli. The lipid raft-associated NHE3 remains at the base, and the nonraft-associated NaPi2 is endocytosed, culminating in decreased Na(+) transport and increased PT flow rate. Antinatriuretic stimuli return the same transporters and regulators to the body of the microvilli associated with an increase in transport activity and decrease in PT flow rate. In summary, ECFV and BP homeostasis are, at least in part, maintained by continuous and acute redistribution of transporter complexes up and down the PT microvilli, which affect regulation of PT sodium reabsorption in response to fluctuations in ECFV, BP, SNS, and RAS.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin IAngiotensin IIBlood PressureExtracellular FluidHomeostasisHumansKidney Tubules, ProximalNatriuresisRenal CirculationSodiumSodium-Hydrogen ExchangersAngiotensin-Converting Enzyme InhibitorsAngiotensin IAngiotensin IISodiumSodium-Hydrogen Exchangers

Identifiers

PMID20106993
PMCPMC2853398
OpenAlexW2058906411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.