ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2010
Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
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- Viruses and asthma: the role of common respiratory viruses in asthma and its potential meaning for SARS-CoV-2.Immunology · 2020Review
- Detection of multiple viral sequences in the respiratory tract samples of suspected Middle East respiratory syndrome coronavirus patients in Jakarta, Indonesia 2015-2016.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Phylogenetic analysis of human rhinoviruses collected over four successive years in Sydney, Australia.Influenza and other respiratory viruses · 2016Article
- EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn.Influenza and other respiratory viruses · 2016Article
- Rhinoviruses and Their Receptors: Implications for Allergic Disease.Current allergy and asthma reports · 2016Review
- Comparative Genetic Analyses of Human Rhinovirus C (HRV-C) Complete Genome from Malaysia.Frontiers in microbiology · 2016Article
- Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma.The Journal of allergy and clinical immunology · 2015Article
- Propagation of rhinovirus-C strains in human airway epithelial cells differentiated at air-liquid interface.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Rhinovirus-induced VP1-specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms.EBioMedicine · 2015Article
- Emerging respiratory viruses other than influenza.Clinics in laboratory medicine · 2014Review
- Human rhinovirus induced cytokine/chemokine responses in human airway epithelial and immune cells.PloS one · 2014Article
- Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.Antimicrobial agents and chemotherapy · 2014Article
- Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells.Virology · 2013Article
- Human rhinovirus species and season of infection determine illness severity.American journal of respiratory and critical care medicine · 2012Article
- Clinical and molecular features of human rhinovirus C.Microbes and infection · 2012Review
- Co-circulation of four human coronaviruses (HCoVs) in Queensland children with acute respiratory tract illnesses in 2004.Viruses · 2012Article
- Severity of human rhinovirus infection in immunocompromised adults is similar to that of 2009 H1N1 influenza.Journal of clinical microbiology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman rhinoviruses (HRVs) are associated with more acute respiratory tract infections than any other viral group yet we know little about viral diversity, epidemiology or clinical outcome resulting from infection by strains, in particular the recently identified HRVs.
objectivesTo determine whether HRVC-QCE was a distinct HRV-C strain, by determining its genome and prevalence, by cataloguing genomic features for strain discrimination and by observing clinical features in positive patients. STUDY
designNovel real-time RT-PCRs and retrospective chart reviews were used to investigate a well-defined population of 1247 specimen extracts to observe the prevalence and the clinical features of each HRV-QCE positive case from an in- and out-patient pediatric, hospital-based population during 2003. An objective illness severity score was determined for each HRVC-QCE positive patient.
resultsDifferences in overall polyprotein and VP1 binding pocket residues and the predicted presence of a cis-acting replication element in 1B defined HRVC-QCE as a novel HRV-C strain. Twelve additional HRVC-QCE detections (1.0% prevalence) occurred among infants and toddlers (1-24 months) suffering mild to moderate illness, including fever and cough, who were often hospitalized. HRVC-QCE was frequently detected in the absence of another virus and was the only virus detected in three (23% of HRVC-QCE positives) children with asthma exacerbation and in two (15%) toddlers with febrile convulsion.
conclusionsHRVC-QCE is a newly identified, genetically distinct HRV strain detected in hospitalized children with a range of clinical features. HRV strains should be independently considered to ensure we do not overestimate the HRVs in asymptomatic illness.
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