ReviewTrends in genetics : TIG2010
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.
Review in Trends in genetics : TIG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Pooled it
- Standard deviation of CT radiomic features among malignancies in each individual: prognostic ability in lung cancer patients.Journal of cancer research and clinical oncology · 2023Trial
- The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Discovering predisposing genes for hereditary breast cancer using deep learning.Briefings in bioinformatics · 2024Article
- Germline determinants of aberrant signaling pathways in cancer.NPJ precision oncology · 2024Article
- Molecular methods for colorectal cancer screening: Progress with next-generation sequencing evolution.World journal of gastrointestinal oncology · 2023Review
- Using whole-genome sequencing (WGS) to plot colorectal cancer-related gut microbiota in a population with varied geography.Gut pathogens · 2022Article
- Advancing the Genetics of Lewy Body Disorders with Disease-Modifying Treatments in Mind.Advanced genetics (Hoboken, N.J.) · 2022Article
- Genome-wide analysis of genetic predisposition to common polygenic cancers.Journal of applied genetics · 2022Article
- An Evolution-Based Model of Causation for Aging-Related Diseases and Intrinsic Mortality: Explanatory Properties and Implications for Healthy Aging.Frontiers in public health · 2022Article
- Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition.Scientific reports · 2021Article
- Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancers.Scientific reports · 2021Article
- The PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma.Cancers · 2021Article
- Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers.Genes · 2021Article
- Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics.Genetic epidemiology · 2021Article
- How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers.Frontiers in oncology · 2021Review
- Fecal Bacteria as Non-Invasive Biomarkers for Colorectal Adenocarcinoma.Frontiers in oncology · 2021Article
- Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine.European journal of translational myology · 2020Article
- Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variations.Scientific reports · 2020Article
- Clonal Evolution ofCells · 2019Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Genome-wide association studies (GWAS) using population-based designs have identified many genetic loci associated with risk of a range of complex diseases including cancer; however, each locus exerts a very small effect and most heritability remains unexplained. Family-based pedigree studies have also suggested tentative loci linked to increased cancer risk, often characterized by pedigree-specificity. However, comparison between the results of population- and family-based studies shows little concordance. Explanations for this unidentified genetic 'dark matter' of cancer include phenotype ascertainment issues, limited power, gene-gene and gene-environment interactions, population heterogeneity, parent-of-origin-specific effects, and rare and unexplored variants. Many of these reasons converge towards the concept of genetic heterogeneity that might implicate hundreds of genetic variants in regulating cancer risk. Dissecting the dark matter is a challenging task. Further insights can be gained from both population association and pedigree studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.