ArticleThe Journal of clinical investigation1991
L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 162 citations in OpenAlex.
- Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.The Journal of clinical investigation · 1996Trial
- Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase.Oxidative medicine and cellular longevityTrial
- Promotion of nitric oxide production: mechanisms, strategies, and possibilities.Frontiers in physiology · 2025Review
- Metabolic reprogramming, oxidative stress, and pulmonary hypertension.Redox biology · 2023Review
- Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review.Paediatric drugs · 2020Review
- Nitric Oxide and Endothelial Dysfunction.Critical care clinics · 2020Review
- Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their RegulationPhysiological reviews · 2019Review
- Apolipoprotein E Deficiency Causes Endothelial Dysfunction in the Mouse Retina.Oxidative medicine and cellular longevity · 2019Article
- Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium.Frontiers in physiology · 2013Review
- Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS.American journal of physiology. Heart and circulatory physiology · 2013Article
- Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Role of l-Arginine on Dyslipidemic Conditions of Acute Myocardial Infarction Patients.Indian journal of clinical biochemistry : IJCB · 2012Article
- Nitric oxide synthases: regulation and function.European heart journal · 2012Review
- Nitric oxide and oxidative stress in vascular disease.Pflugers Archiv : European journal of physiology · 2010Review
- Oral supplement of six selective amino acids arrest progression renal failure in uremic patients.International urology and nephrology · 2004Article
- Review
- Clinical implications of endothelial dysfunction.Clinical cardiology · 1998Review
- Therapeutic interventions in endothelial dysfunction: endothelium as a target organ.Clinical cardiology · 1997Review
- The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery.British journal of pharmacology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that normal vascular reactivity could be restored in vessels from hypercholesterolemic animals by exposing them to L-arginine, the precursor of endothelium-derived relaxing factor (EDRF). Basilar arteries were harvested from New Zealand white rabbits fed normal chow or that supplemented with 2% cholesterol for 10 wk. Vessels were cannulated for perfusion at physiologic pressure. Changes in vessel diameter were monitored by videomicroscopy. In comparison to normal vessels, those from hypercholesterolemic animals vasoconstricted more to KCl, endothelin (E), and 5-hydroxytryptamine (5-HT). Conversely, vasodilation to acetylcholine (ACh) (but not that to verapamil) was significantly impaired in the hypercholesterolemic animals. In vitro administration of L-arginine (3 mM) for 45 min normalized vasodilation to ACh and vasoconstriction to E, 5-HT, and KCl in the isolated vessels from hypercholesterolemic animals. This effect was stereospecific, since D-arginine had no effect. To conclude, these data confirm that hypercholesterolemia attenuates endothelium-derived relaxation, and enhances the sensitivity of these vessels to vasoconstrictors. In vitro administration of L-arginine normalized vascular reactivity of isolated vessels from hypercholesterolemic animals. Thus, hypercholesterolemia induces a reversible endothelial dysfunction that may be corrected by supplying the precursor of EDRF, L-arginine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.