ArticleCritical care (London, England)2010
The use of a blood conservation device to reduce red blood cell transfusion requirements: a before and after study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review.Critical care (London, England) · 2019Pooled it
- A Simple "Blood-Saving Bundle" Reduces Diagnostic Blood Loss and the Transfusion Rate in Mechanically Ventilated Patients.PloS one · 2015Trial
- Extract from the 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery - Patient Blood Management.Blood transfusion = Trasfusione del sangue · 2024Review
- Effect of using smaller blood volume tubes and closed blood collection devices on total blood loss in patients undergoing major cardiac and vascular surgery.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study.PloS one · 2021Observational
- Article
- "Simplified International Recommendations for the Implementation of Patient Blood Management" (SIR4PBM).Perioperative medicine (London, England) · 2017Article
- Blood conservation devices in critical care: a narrative review.Annals of intensive care · 2013Review
- Anemia in critical illness: insights into etiology, consequences, and management.American journal of respiratory and critical care medicine · 2012Review
- A Standard Push-Pull Protocol for Waste-Free Sampling in the Pediatric Intensive Care Unit.Journal of infusion nursing : the official publication of the Infusion Nurses SocietyArticle
- An indigenous modification to ensure closed blood sampling.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnaemia and the associated need for packed red blood cell (PRBC) transfusions are common in patients admitted to the intensive care unit (ICU). Among many causes, blood losses from repeated diagnostic tests are contributory.
methodsThis is a before and after study in a medical ICU of a university hospital. We used a closed blood conservation device (Venous Arterial blood Management Protection, VAMP, Edwards Lifesciences, Irvine, CA, USA) to decrease PRBC transfusion requirements. We included all adult (> or =18 years) patients admitted to the ICU with indwelling arterial catheters, who were expected to stay more than 24 hours and were not admitted for active gastrointestinal or any other bleeding. We collected data for six months without VAMP (control group) immediately followed by nine months (active group) with VAMP. A restrictive transfusion strategy in which clinicians were strongly discouraged from any routine transfusions when haemoglobin (Hb) levels were above 7.5 g/dL was adopted during both periods.
resultsEighty (mean age 61.6 years, 49 male) and 170 patients (mean age 60.5 years, 101 male) were included in the control and active groups respectively. The groups were comparable for age, gender, Acute Physiology and Chronic Health Evaluation (APACHE) II score, need for renal replacement therapy, length of stay, and Hb levels on discharge and at transfusion. The control group had higher Hb levels on admission (12.4 +/- 2.5 vs. 11.58 +/- 2.8 gm/dL, P = 0.02). Use of a blood conservation device was significantly associated with decreased requirements for PRBC transfusion (control group 0.131 unit vs. active group 0.068 unit PRBC/patient/day, P = 0.02) on multiple linear regression analysis. The control group also had a greater decline in Hb levels (2.13 +/- 2.32 vs. 1.44 +/- 2.08 gm/dL, P = 0.02) at discharge.
conclusionsThe use of a blood conservation device is associated with 1) reduced PRBC transfusion requirements and 2) a smaller decrease in Hb levels in the ICU.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.