ArticleThe European journal of neuroscience2010
BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons.
Article in The European journal of neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties.Pflugers Archiv : European journal of physiology · 2022Pooled it
- Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis.Frontiers in cellular neuroscience · 2021Article
- Oxaliplatin Depolarizes the IB4Frontiers in molecular neuroscience · 2021Article
- KFrontiers in cellular neuroscience · 2020Review
- Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.Neuron · 2019Article
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular CaCell calcium · 2017Article
- Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Galanin and its receptor system promote the repair of injured sciatic nerves in diabetic rats.Neural regeneration research · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Article
- Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy.Neuroscience · 2015Article
- Article
- Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia.Journal of neurophysiology · 2015Article
- The properties, distribution and function of Na(+)-Ca(2+) exchanger isoforms in rat cutaneous sensory neurons.The Journal of physiology · 2014Article
- Regulating excitability of peripheral afferents: emerging ion channel targets.Nature neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The biophysical properties and distribution of voltage-dependent, Ca(2+) -modulated K(+) (BK(Ca)) currents among subpopulations of acutely dissociated DiI-labeled cutaneous sensory neurons from the adult rat were characterized with whole-cell patch-clamp techniques. BK(Ca) currents were isolated from total K(+) current with iberiotoxin, charybdotoxin or paxilline. There was considerable variability in biophysical properties of BK(Ca) currents. There was also variability in the distribution of BK(Ca) current among subpopulations of cutaneous dorsal root ganglia (DRG) neurons. While present in each of the subpopulations defined by cell body size, IB4 binding or capsaicin sensitivity, BK(Ca) current was present in the vast majority (> 90%) of small-diameter IB4+ neurons, but was present in only a minority of neurons in subpopulations defined by other criteria (i.e. small-diameter IB4-). Current-clamp analysis indicated that in IB4+ neurons, BK(Ca) currents contribute to the repolarization of the action potential and adaptation in response to sustained membrane depolarization, while playing little role in the determination of action potential threshold. Reverse transcriptase-polymerase chain reaction analysis of mRNA collected from whole DRG revealed the presence of multiple splice variants of the BK(Ca) channel alpha-subunit, rslo and all four of the accessory beta-subunits, suggesting that heterogeneity in the biophysical and pharmacological properties of BK(Ca) current in cutaneous neurons reflects, at least in part, the differential distribution of splice variants and/or beta-subunits. Because even a small decrease in BK(Ca) current appears to have a dramatic influence on excitability, modulation of this current may contribute to sensitization of nociceptive afferents observed following tissue injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.