ArticleEuropean journal of immunology2010
Lineage-specific transcription factors in unexpected places.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Immune heterogeneity in neuroinflammation: dendritic cells in the brain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.PloS one · 2013Article
- Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.Immunological investigations · 2012Review
- Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog.Immunology · 2011Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Foxp3 is a transcription factor closely associated with the Treg lineage in humans and mice. In the immune system, Foxp3 appears highly specific for Treg, and is not known to be expressed by other immune cell types. In this issue of the European Journal of Immunology, an article reports that human DC transfected with ectopic Foxp3 unexpectedly acquire an immunosuppressive phenotype. Foxp3-transfected DC suppressed proliferation of naive T cells, and biased the differentiation of CD4(+) cells into Treg-like cells that themselves expressed Foxp3. The molecular mechanism of these effects required functional activity of the immunoregulatory enzyme IDO. Thus, a transcription factor not native to DC nevertheless conferred elements of a regulatory phenotype following ectopic expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.