Evidence map›Paper›PMID 20104522›Full record

ArticleInternational journal of cancer2010

Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.

Zhihong Gong, Elizabeth A Holly, Furong Wang, June M Chan, Paige M Bracci

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 10 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 10 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  9. Vitamin E intake and pancreatic cancer risk: a meta-analysis of observational studies.Medical science monitor : international medical journal of experimental and clinical research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhihong GongDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA 94118-1944, USA.
Elizabeth A Holly
Furong Wang
June M Chan
Paige M Bracci
University of California, San Francisco · USIn-Q-Tel · USStanford University · US

Funding

Molecular Epidemiology of Pancreatic CancerR01CA109767 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRACCI, PAIGE M. · 2005 to 2010
$3.2M
Pancreas cancer analysis-SF Bay Area case-control studyR03CA108370 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2004 to 2005
$152k
MTHFR POLYMORPHISMS IN PANCREATIC CANCER IN SF BAY AREAR03CA089726 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2002
$148k
PANCREATIC CANCER CASE CONTROL STUDY IN SAN FRANCISCOR01CA059706 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 1994 to 1998
–
NCI NIH HHS CA108370NCI NIH HHS CA109767NCI NIH HHS CA59706NCI NIH HHS CA89726NCI NIH HHS N01 PC035136NCI NIH HHS N01-PC-35136NCI NIH HHS R01 CA109767NCI NIH HHS R03 CA089726NCI NIH HHS R03 CA108370PHS HHS U55/CCR921930-02
6 · The paper itself

Abstract

There are no well-established modifiable risk factors for pancreatic cancer except smoking. Some dietary factors have been associated with pancreatic cancer risk and require further study. We examined the associations among intake of specific fatty acids and antioxidants and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area. Unconditional logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CI) as estimates of relative risk. Positive associations were observed for high levels of the 8 individual saturated fatty acids (4th vs. 1st quartile: ORs ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated palmitoleic and oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI: 1.1-1.9); both p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5 (95% CI: 1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high levels of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92); p(trend) = 0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR = 0.47 (95% CI: 0.25-0.90)]. An inverse association was also observed for high total intake of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94); p(trend) = 0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) = 0.01]. Although similar decreased risks were also observed for high supplemental intake of these 2 vitamins (both p(trend) < 0.01), no association was observed for intake from food alone. These results support the hypotheses that a high intake of saturated and certain monounsaturated fatty acids may increase the risk of pancreatic cancer, whereas greater intake of omega-3 fatty acids, vitamins C and E may reduce the risk.

Indexed as

Dietary SupplementsAdenocarcinomaAdultAgedAged, 80 and overAntioxidantsCase-Control StudiesFatty AcidsFemaleFollow-Up StudiesHumansMaleMiddle AgedPancreatic NeoplasmsPrognosisSan FranciscoAntioxidantsFatty AcidsVitamins

Identifiers

PMID20104522
PMCPMC2930138
OpenAlexW2055966597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.