ReviewJournal of bioenergetics and biomembranes1991
Cell regulation by sphingosine and more complex sphingolipids.
Review in Journal of bioenergetics and biomembranes, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 241 citations in OpenAlex.
- Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.The EMBO journal · 2025Article
- Application of sphingolipid-based nanocarriers in drug delivery: an overview.Therapeutic delivery · 2024Review
- Effect of galactosylceramide on stratum corneum intercellular lipid synthesis in a three-dimensional cultured human epidermis model.Biochemistry and biophysics reports · 2021Article
- Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties.Scientific reports · 2017Article
- Ceramide and ceramide 1-phosphate in health and disease.Lipids in health and disease · 2010Review
- Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis.Cancer research · 2009Article
- Rafts as missing link between multidrug resistance and sphingolipid metabolism.The Journal of membrane biology · 2005Review
- A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling.Pediatric surgery international · 2004Article
- Diacylglycerol generated during sphingomyelin synthesis is involved in protein kinase C activation and cell proliferation in Madin-Darby canine kidney cells.The Biochemical journal · 2003Article
- Glycosyltransferases in different brain regions during chick embryo development.Neurochemical research · 2002Article
- A novel sphingophosphonolipid head group 1-hydroxy-2-aminoethyl phosphonate in Bdellovibrio stolpii.Lipids · 2001Article
- An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.Environmental health perspectives · 2001Review
- Activation of cPLA2, PKC, and ERKs in the rat cerebral cortex during ischemia/reperfusion.Neurochemical research · 1999Article
- Screening of fungal species for fumonisin production and fumonisin-like disruption of sphingolipid biosynthesis.Mycopathologia · 1999Article
- Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae.Journal of bacteriology · 1997Article
- Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1.Glycoconjugate journal · 1996Article
- The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes.Glycoconjugate journal · 1996Article
- Chronic toxicity of fumonisins from Fusarium moniliforme culture material (M-1325) to mink.Archives of environmental contamination and toxicology · 1995Article
- Activation of a retinoblastoma-protein-dependent pathway by sphingosine.The Biochemical journal · 1995Article
- Sphingolipid metabolites: members of a new class of lipid second messengers.The Journal of membrane biology · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Sphingolipids have the potential to regulate cell behavior at essentially all levels of signal transduction. They serve as cell surface receptors for cytoskeletal proteins, immunoglobulins, and some bacteria; as modifiers of the properties of cell receptors for growth factors (and perhaps other agents); and as activators and inhibitors of protein kinases, ion transporters, and other proteins. Furthermore, the biological activity of these compounds resides not only in the more complex species (e.g., sphingomyelin, cerebrosides, gangliosides, and sulfatides), but also in their turnover products, such as the sphingosine backbone which inhibits protein kinase C and activates the EGF-receptor kinase, inter alia. Since sphingolipids change with cell growth, differentiation, and neoplastic transformation, they could be vital participants in the regulation of these processes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.