Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2010
Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04019301 (Caring for Caregivers With Mind-body Exercise), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caring for Caregivers With Mind-body Exercise
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A systematic review and psychometric evaluation of resilience measurement scales for people living with dementia and their carers.BMC medical research methodology · 2022Pooled it
- Towards conceptual convergence: A systematic review of psychological resilience in family caregivers of persons living with chronic neurological conditions.Health expectations : an international journal of public participation in health care and health policy · 2022Pooled it
- Citalopram versus other anti-depressive agents for depression.The Cochrane database of systematic reviews · 2012Pooled it
- Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial.Psychoneuroendocrinology · 2013Trial
- Enhancing quality of life and mastery of informal caregivers of high-grade glioma patients: a randomized controlled trial.Journal of neuro-oncology · 2013Trial
- A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity.International journal of geriatric psychiatry · 2013Trial
- Interventions to Foster Resilience in Family Caregivers of People with Alzheimer's Disease: A Scoping Review.International journal of environmental research and public health · 2024Article
- Examining the Rationale for Studying Psychedelic-Assisted Psychotherapy for the Treatment of Caregiver Distress.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- A continuum of languishing to flourishing: exploring experiences of psychological resilience in multiple sclerosis family caregivers.International journal of qualitative studies on health and well-being · 2022Article
- Qigong mind-body program for caregivers of cancer patients: design of a pilot three-arm randomized clinical trial.Pilot and feasibility studies · 2021Article
- The relationship between the positive aspects of caring and the personal growth of caregivers of patients with advanced oncological illness : Postraumattic growth and caregiver.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Resilience and burden in caregivers of older adults: moderating and mediating effects of perceived social support.BMC psychiatry · 2018Article
- Editorial: Resilience, R.M. Guimarães.The journal of nutrition, health & aging · 2018Article
- The Importance of Coping in Critically Ill Patients.Critical care medicine · 2016Article
- Association Between Resilience and Family Member Psychologic Symptoms in Critical Illness.Critical care medicine · 2016Article
- Depressive symptoms in neurodegenerative diseases.World journal of clinical cases · 2015Review
- Why does placement of persons with Alzheimer's disease into long-term care improve caregivers' well-being? Examination of psychological mediators.Psychology and aging · 2014Article
- Caregiver health: health of caregivers of Alzheimer's and other dementia patients.Current psychiatry reports · 2013Article
- Article
- The interface between depression and dementia: where are we with this important frontier?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study examined the potential of an antidepressant drug, escitalopram, to improve depression, resilience to stress, and quality of life in family dementia caregivers in a randomized placebo-controlled double-blinded trial.
methodsForty family caregivers (43-91 years of age, 25 children and 15 spouses; 26 women) who were taking care of their relatives with Alzheimer disease were randomized to receive either escitalopram 10 mg/day or placebo for 12 weeks. Severity of depression, resilience, burden, distress, quality of life, and severity of care-recipient's cognitive and behavioral disturbances were assessed at baseline and over the course of the study. The Hamilton Depression Rating Scale scores at baseline ranged between 10 and 28. The groups were stratified by the diagnosis of major and minor depression.
resultsMost outcomes favored escitalopram over placebo. The severity of depression improved, and the remission rate was greater with the drug compared with placebo. Measures of anxiety, resilience, burden, and distress improved on escitalopram compared with placebo. DISCUSSION: Among caregivers, this small randomized controlled trial found that escitalopram use resulted in improvement in depression, resilience, burden and distress, and quality of life. Our results need to be confirmed in a larger sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.