Evidence map›Paper›PMID 20103768›Full record

ArticleJournal of leukocyte biology2010

Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.

Subhashini Arimilli, Sharad K Sharma, Rama Yammani, Sean D Reid, Griffith D Parks, Martha A Alexander-Miller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Subhashini Arimilli1. Room 5140 Gray Building, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Sharad K Sharma
Rama Yammani
Sean D Reid
Griffith D Parks
Martha A Alexander-Miller
Wake Forest University · US

Funding

Cellular Immune Response to Respiratory InfectionR01HL071985 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALEXANDER-MILLER, MARTHA ANN · 2004 to 2010
$2.4M
NHLBI NIH HHS R01 HL071985
6 · The paper itself

Abstract

CD8(+) T cells play a critical role in the clearance of respiratory pathogens. Thus, it is surprising that functional inactivation of lung effectors has been observed in many models of viral infection. Currently, the molecular defect responsible for the shut-off of function in these cells is unknown. In the present study, we addressed this question using a model of respiratory infection with the paramyxovirus SV5. Nonfunctional cells were found to exhibit decreases in SOCE, resulting in reduced NFAT1 activation. Notably, function could be restored by the provision of increased levels of extracellular calcium. The reduced ability to mobilize calcium was associated with reduced expression of ORAI1, the CRAC channel subunit. These findings reveal a previously unknown mechanism for the negative regulation of function in effector T cells.

Indexed as

Calcium SignalingAnimalsBlotting, WesternCalciumCalcium ChannelsCD8-Positive T-LymphocytesCells, CulturedCytokinesElectrophysiologyFemaleImmunizationLungMembrane GlycoproteinsMiceMice, Inbred BALB CNFATC Transcription FactorsCalciumCalcium ChannelsCytokinesMembrane GlycoproteinsNfatc2 protein, mouseNFATC Transcription FactorsORAI1 ProteinOrai1 protein, mouseRNA, MessengerStim1 protein, mouseStromal Interaction Molecule 1

Identifiers

PMID20103768
PMCPMC2872535
OpenAlexW2120352392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.