ReviewCancer prevention research (Philadelphia, Pa.)2010
Cancer chemoprevention locks onto a new polyamine metabolic target.
Review in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Dietary polyamine intake and risk of colorectal adenomatous polyps.The American journal of clinical nutrition · 2012Trial
- The tumor-nerve circuit in breast cancer.Cancer metastasis reviews · 2023Review
- Eight-gene metabolic signature related with tumor-associated macrophages predicting overall survival for hepatocellular carcinoma.BMC cancer · 2021Article
- Metabolic gene alterations impact the clinical aggressiveness and drug responses of 32 human cancers.Communications biology · 2019Article
- Quantitative metabolomics for investigating the value of polyamines in the early diagnosis and therapy of colorectal cancer.Oncotarget · 2018Article
- Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs.Oncotarget · 2017Article
- c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.Oncotarget · 2016Article
- ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers.American journal of cancer research · 2016Article
- The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection.Oxidative medicine and cellular longevity · 2016Article
- Dietary polyamine intake and colorectal cancer risk in postmenopausal women.The American journal of clinical nutrition · 2015Observational
- Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells.The Journal of biological chemistry · 2015Article
- Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells.Experimental & molecular medicine · 2011Article
- Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.The Journal of biological chemistry · 2011Article
- Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).The Biochemical journal · 2011Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.