ArticleMetabolism: clinical and experimental2010
Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus.
Article in Metabolism: clinical and experimental, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role?Medicina (Kaunas, Lithuania) · 2025Article
- Review
- The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.Cardiovascular engineering and technology · 2021Review
- Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease.Endocrine reviews · 2021Review
- Functional Tuning of Intrinsic Endothelial Ca2+ Dynamics in Swine Coronary Arteries.Circulation research · 2016Article
- Mechanosensing at the vascular interface.Annual review of biomedical engineering · 2014Review
- Do patients with type 1 and type 2 diabetes really have an impaired endothelial function? A population-based propensity score matching analysis.Cardiovascular diabetology · 2013Article
- Combined examination of glyceryl trinitrate-mediated vascular dilation with flow-mediated vascular dilation is essential for assessment of vascular function in type 2 diabetes.Journal of diabetes investigation · 2013Article
- High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx.PloS one · 2013Article
- Evaluation of the EndoPAT as a Tool to Assess Endothelial Function.International journal of vascular medicine · 2012Article
- The endothelial dysfunction in patients with type 2 diabetes mellitus is associated with IL-6 gene promoter polymorphism in Chinese population.Endocrine · 2011Article
- Characterization of macro-and microvascular function and structure in patients with type 2 diabetes mellitus.American journal of cardiovascular disease · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The goal of this study was to determine if individuals with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) had greater endothelial dysfunction (ED) than individuals with only CAD. Flow-mediated dilation (FMD), calculated as percentage increase in brachial artery diameter in response to postischemic blood flow, was measured after an overnight fast in 2 cohorts. The first cohort included 76 participants in the Northern Manhattan Study with CAD; 25 also had T2DM. The second cohort was composed of 27 individuals with both T2DM and CAD who were participants in a study of postprandial lipemia. Combined, we analyzed 103 patients with CAD: 52 with T2DM (T2DM+) and 51 without T2DM (T2DM-). The 52 CAD T2DM+ subjects had a mean FMD of 3.9% +/- 3.2%, whereas the 51 CAD T2DM- subjects had a greater mean FMD of 5.5% +/- 4.0% (P < .03). An investigation of various confounders known to affect FMD identified age and body mass index as the only significant covariates in a multiple regression model. Adjusting for age and body mass index, we found that FMD remained lower in T2DM+ subjects compared with T2DM- subjects (difference, -1.99%; P < .03). In patients with CAD, the concomitant presence of T2DM is independently associated with greater ED, as measured by FMD. This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM.
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