ArticleBrain, behavior, and immunity2010
Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis?
Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review.Frontiers in immunology · 2022Pooled it
- Early clearance of Chikungunya virus in children is associated with a strong innate immune response.Scientific reports · 2016Pooled it
- Association between serum cytokine and neuron-specific enolase levels and the core symptoms of autism spectrum disorder.IBRO neuroscience reports · 2026Article
- Article
- A Transcriptomic Dataset of Embryonic Murine Telencephalon of Fmr1-Deficient Mice.Scientific data · 2025Article
- Lipopolysaccharide-induced sickness behavior is not altered in male Fmr1-deficient mice.Brain and behavior · 2023Article
- An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis.Communications biology · 2023Article
- Biomarker prediction in autism spectrum disorder using a network-based approach.BMC medical genomics · 2023Article
- Characterization of a mGluR5 Knockout Rat Model with Hallmarks of Fragile X Syndrome.Life (Basel, Switzerland) · 2022Article
- Increased Monocyte Production of IL-6 after Toll-like Receptor Activation in Children with Autism Spectrum Disorder (ASD) Is Associated with Repetitive and Restricted Behaviors.Brain sciences · 2022Article
- Article
- An "Omic" Overview of Fragile X Syndrome.Biology · 2021Review
- Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8.Pediatric research · 2021Article
- Salivary Cytokine Profile as a Possible Predictor of Autism Spectrum Disorder.Journal of clinical medicine · 2020Article
- The RNA-binding fragile-X mental retardation protein and its role beyond the brain.Biophysical reviews · 2020Review
- Therapeutic Effects of the In Vitro Cultured Human Gut Microbiota as Transplants on Altering Gut Microbiota and Improving Symptoms Associated with Autism Spectrum Disorder.Microbial ecology · 2020Article
- Reduced serum levels of pro-inflammatory chemokines in fragile X syndrome.BMC neurology · 2020Article
- Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome.Physiology & behavior · 2020Article
- Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction.Frontiers in cell and developmental biology · 2020Article
- Molecular Biomarkers in Fragile X Syndrome.Brain sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFragile X syndrome (FXS) is a single-gene disorder with a broad spectrum of involvement and a strong association with autism. Altered immune responses have been described in autism and there is potential that in children with FXS and autism, an abnormal immune response may play a role.
objectivesTo delineate specific patterns of cytokine/chemokine profiles in individuals with FXS with and without autism and to compare them with typical developing controls.
methodsAge matched male subjects were recruited through the M.I.N.D. Institute and included: 19 typically developing controls, 64 subjects with FXS without autism and 40 subjects with FXS and autism. Autism diagnosis was confirmed with ADOS, ADI-R and DSM IV criteria. Plasma was isolated and cytokine and chemokine production was assessed by Luminex multiplex analysis.
resultsPreliminary observations indicate significant differences in plasma protein levels of a number of cytokines, including IL-1alpha, and the chemokines; RANTES and IP-10, between the FXS group and the typical developing controls (p<0.01). In addition, significant differences were observed between the FXS group with autism and the FXS without autism for IL-6, eotaxin, MCP-1 (p<0.04).
conclusionsIn this study, the first of its kind, we report a significantly altered cytokine profile in FXS. The characterization of an immunological profile in FXS with and without autism may help to elucidate if an abnormal immune response may play a role and help to identify mechanisms important in the etiology of autism both with and without FXS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.