ArticleDevelopmental biology2010
Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Actomyosin contractility modulates Wnt signaling through adherens junction stability.Molecular biology of the cell · 2019Article
- Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia.Oncogene · 2017Article
- Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis.Scientific reports · 2016Article
- miR-8 modulates cytoskeletal regulators to influence cell survival and epithelial organization in Drosophila wings.Developmental biology · 2016Article
- Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation.Current biology : CB · 2016Article
- The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis.Biochimica et biophysica acta · 2015Article
- Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer.Cellular and molecular life sciences : CMLS · 2014Review
- Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development.PloS one · 2012Article
- A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.Development (Cambridge, England) · 2011Article
- Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The tumor suppressor Adenomatous polyposis coli (APC) is a negative regulator of Wnt signaling and functions in cytoskeletal organization. Disruption of human APC in colonic epithelia initiates benign polyps that progress to carcinoma following additional mutations. The early events of polyposis are poorly understood, as is the role of canonical Wnt signaling in normal epithelial architecture and morphogenesis. To determine the consequences of complete loss of APC in a model epithelium, we generated APC2 APC1 double null clones in the Drosophila wing imaginal disc. APC loss leads to segregation, apical constriction, and invagination that result from transcriptional activation of canonical Wnt signaling. Further, we show that Wnt-dependent changes in cell fate can be decoupled from Wnt-dependent changes in cell shape. Wnt activation is reported to upregulate DE-cadherin in wing discs, and elevated DE-cadherin is thought to promote apical constriction. We find that apical constriction and invagination of APC null tissue are independent of DE-cadherin elevation, but are dependent on Myosin II activity. Further, we show that disruption of Rho1 suppresses apical constriction and invagination in APC null cells. Our data suggest a novel link between canonical Wnt signaling and epithelial structure that requires activation of the Rho1 pathway and Myosin II.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.