ArticleBMC genomics2010
Changes in the genomic content of circulating Bordetella pertussis strains isolated from the Netherlands, Sweden, Japan and Australia: adaptive evolution or drift?
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Prevalence and Evolutionary Implications of Genome Rearrangements in Bacteria.Genome biology and evolution · 2026Article
- Global disease burden and trends of pertussis in individuals under 20 years old: 1990-2021-insights from the global burden of disease study 2021.Translational pediatrics · 2025Article
- Global, regional, and national burdens of pertussis among adults: a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data.Infectious diseases of poverty · 2025Article
- Towards comprehensive understanding of bacterial genetic diversity: large-scale amplifications inMicrobial genomics · 2022Article
- Recent increase in pertussis incidence in Korea: an age-period-cohort analysis.Epidemiology and health · 2021Article
- Fundamental differences in physiology ofMicrobial genomics · 2020Article
- Comparative genomics of whole-cell pertussis vaccine strains from India.BMC genomics · 2020Article
- The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement.Journal of bacteriology · 2017Article
- Article
- Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira.Scientific reports · 2016Article
- The Pertussis resurgence: putting together the pieces of the puzzle.Tropical diseases, travel medicine and vaccines · 2016Review
- Protecting Newborns Against Pertussis: Treatment and Prevention Strategies.Paediatric drugs · 2015Review
- Bordetella pertussis evolution in the (functional) genomics era.Pathogens and disease · 2015Review
- Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis.Scientific reports · 2015Article
- A Functional Tricarboxylic Acid Cycle Operates during Growth of Bordetella pertussis on Amino Acid Mixtures as Sole Carbon Substrates.PloS one · 2015Article
- Investigating genome reduction of Bordetella pertussis using a multiplex PCR-based reverse line blot assay (mPCR/RLB).BMC research notes · 2014Article
- Article
- Recent trends of antigenic variation in Bordetella pertussis isolates in Korea.Journal of Korean medical science · 2014Article
- Age related differences in dynamics of specific memory B cell populations after clinical pertussis infection.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBordetella pertussis is the causative agent of human whooping cough (pertussis) and is particularly severe in infants. Despite worldwide vaccinations, whooping cough remains a public health problem. A significant increase in the incidence of whooping cough has been observed in many countries since the 1990s. Several reasons for the re-emergence of this highly contagious disease have been suggested. A particularly intriguing possibility is based on evidence indicating that pathogen adaptation may play a role in this process. In an attempt to gain insight into the genomic make-up of B. pertussis over the last 60 years, we used an oligonucleotide DNA microarray to compare the genomic contents of a collection of 171 strains of B. pertussis isolates from different countries.
resultsThe CGH microarray analysis estimated the core genome of B. pertussis, to consist of 3,281 CDSs that are conserved among all B. pertussis strains, and represent 84.8% of all CDSs found in the 171 B. pertussis strains. A total of 64 regions of difference consisting of one or more contiguous CDSs were identified among the variable genes. CGH data also revealed that the genome size of B. pertussis strains is decreasing progressively over the past 60 years. Phylogenetic analysis of microarray data generated a minimum spanning tree that depicted the phylogenetic structure of the strains. B. pertussis strains with the same gene content were found in several different countries. However, geographic specificity of the B. pertussis strains was not observed. The gene content was determined to highly correlate with the ptxP-type of the strains.
conclusionsAn overview of genomic contents of a large collection of isolates from different countries allowed us to derive a core genome and a phylogenetic structure of B. pertussis. Our results show that B. pertussis is a dynamic organism that continues to evolve.
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