ArticleBMC medical genetics2010
The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Breaking Barriers in Functional Dyspepsia: A Systematic Review and Meta-analysis on Duodenal Tight Junction Protein Expression.Journal of neurogastroenterology and motility · 2024Pooled it
- Association of genetic variants in GNβ3 with functional dyspepsia: a meta-analysis.Digestive diseases and sciences · 2014Pooled it
- Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.The American journal of gastroenterology · 2017Trial
- Article
- Double-blind, randomized, 8-week multicenter study of the efficacy and safety of STW 5-IIJGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2019Review
- A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.European journal of pain (London, England) · 2018Article
- Association of hemodynamics during caesarean section, outcomes after caesarean section and hormone changes with different anesthesia in pregnant women with severe pulmonary arterial hypertension.Experimental and therapeutic medicine · 2018Article
- The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis.Gastroenterology research and practice · 2016Review
- Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World.Journal of neurogastroenterology and motility · 2015Article
- Gene polymorphisms associated with functional dyspepsia.World journal of gastroenterology · 2015Review
- Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology.Journal of gastroenterology · 2015Review
- Genetic polymorphism in pathogenesis of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- G protein β3 subunit polymorphism and long-term prognosis of functional dyspepsia.Gut and liver · 2014Article
- Genetic contribution to motility disorders of the upper gastrointestinal tract.World journal of gastrointestinal pathophysiology · 2013Article
- Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria.Nature reviews. Gastroenterology & hepatology · 2013Review
- Overlap of functional dyspepsia and GERD--diagnostic and treatment implications.Nature reviews. Gastroenterology & hepatology · 2013Review
- Functional Dyspepsia in Review: Pathophysiology and Challenges in the Diagnosis and Management due to Coexisting Gastroesophageal Reflux Disease and Irritable Bowel Syndrome.Gastroenterology research and practice · 2013Article
- Why dyspepsia can occur without organic disease: pathogenesis and management of functional dyspepsia.Journal of gastroenterology · 2012Review
- Is There Enough Evidence for the Association of GNβ3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?Journal of neurogastroenterology and motility · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein beta3 (GNB3) subunit gene polymorphism (C825T); however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up.
methodsSubjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The presence of the GNB3 C825T polymorphism was then evaluated and logistic regression analysis was used to test all variables.
resultsThe GNB3 genotype distribution in subjects without dyspepsia was 191 CC (25.1%), 368 TC (48.4%), and 202 TT (26.5%) and 17 CC (25.0%), 29 TC (42.6%), and 22 TT (32.4%) in subjects with dyspepsia. No significant correlation was found between the GNB3 825TT genotype and dyspepsia. However, the TT genotype was significantly associated with subjects with EPS-like symptoms (odds ratio (OR) = 2.00, 95% confidence interval (CI); 1.07-3.76) compared to the CT/CC genotype adjusted for gender and age. No significant correlation was found between GNB3 polymorphism and PDS-like symptoms (OR = 0.68, 95% CI; 0.31-1.51). With the exclusion of subjects with both EPS- and PDS-like symptoms, only the TT genotype was significantly associated with EPS-like symptoms (OR = 2.73, 95% CI; 1.23-5.91).
conclusionThe homozygous GNB3 825T allele influences the susceptibility to EPS-like dyspepsia.
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