ArticleImmunology2010
Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection.
Article in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
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- Vaccination with Mincle agonist UM-1098 and mycobacterial antigens induces protective Th1 and Th17 responses.NPJ vaccines · 2024Article
- Identification of KeyInternational journal of molecular sciences · 2023Article
- Biliatresone induces cholangiopathy in C57BL/6J neonates.Scientific reports · 2023Article
- Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure.Journal of neuroinflammation · 2023Article
- A novel cold-chain free VCG-based subunit vaccine protects againstFrontiers in immunology · 2023Article
- Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity.Cancer drug resistance (Alhambra, Calif.) · 2023Article
- Host Immunity Influences the Composition of Murine Gut Microbiota.Frontiers in immunology · 2022Article
- Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation.Journal of innate immunity · 2021Article
- The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs.Microbes and infection · 2020Article
- Immunogenicity of Protein Pharmaceuticals.Journal of pharmaceutical sciences · 2019Review
- Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice.Malaria journal · 2019Article
- Differences in innate IFNγ and IL-17 responses to Bordetella pertussis between BALB/c and C57BL/6 mice: role of γδT cells, NK cells, and dendritic cells.Immunologic research · 2017Article
- Article
- TheFrontiers in microbiology · 2017Article
- Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.Journal of cellular and molecular medicine · 2016Article
- Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis.Journal of the American Heart Association · 2016Article
- Article
- Murine models of Candida gastrointestinal colonization and dissemination.Eukaryotic cell · 2013Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the phenotypic basis for genetically determined differences in susceptibility and resistance to Chlamydia muridarum pulmonary infection using BALB/c and C57BL/6 mice. Following C. muridarum intranasal inoculation, the intensity of infection was very different between BALB/c and C57BL/6 beginning as early as 3 days post-infection. Intrapulmonary cytokine patterns also differed at early time-points (days 2 and 4) between these two strains of mice. The early recruitment of neutrophils to lung tissue was greater in BALB/c than in C57BL/6 mice and correlated with a higher number of inclusion forming units (IFU) of C. muridarum. At day 12 post-infection, BALB/c mice continued to demonstrate a greater burden of infection, significantly higher lung cytokine levels for tumour necrosis factor-alpha and interleukin-17 (IL-17) and a significantly lower level for interferon-gamma than did C57BL/6 mice. In vitro, bone-marrow-derived dendritic cells (BMDCs) from BALB/c mice underwent less functional maturation in response to C. muridarum infection than did BMDCs from C57BL/6 mice. The BMDCs of BALB/c mice expressed lower levels of activation markers (CD80, CD86, CD40 and major histocompatibility complex class II) and secreted less IL-12 and more IL-23 than BMDCs from C57BL/6 mice. Overall, the data demonstrate that the differences exhibited by BALB/c and C57BL/6 mice following C. muridarum pulmonary infection are associated with differences in early innate cytokine and cellular responses that are correlated with late differences in T helper type 17 versus type 1 adaptive immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.