ArticleImmunology2010
Hepcidin messenger RNA expression in human lymphocytes.
Article in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Serum Hepcidin Levels are Associated with Poor Outcomes of Patients with Severe Traumatic Brain Injury: A Two-Center Observational Analytical Study.International journal of general medicine · 2026Article
- Hepcidin and Tissue-Specific Iron Regulatory Networks.Advances in experimental medicine and biology · 2025Review
- Blood Level of Nitric Oxide Metabolites and Expression of Genes Regulating NO Synthesis in Early Forms of Non-Alcoholic Fatty Liver Disease.Bulletin of experimental biology and medicine · 2024Article
- [Influencing factors of iron metabolism assessment in patients with myelodysplastic syndrome: A retrospective study].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Article
- The novel SLC40A1 (T419I) variant results in a loss-of-function phenotype and may provide insights into the mechanism of large granular lymphocytic leukemia and pure red cell aplasia.Blood science (Baltimore, Md.) · 2022Article
- Relation of hepcidin gene expression in blood mononuclear cells with iron overload severity among β-thalassemia major patients.Molecular biology reports · 2020Article
- Zeolites ameliorate asbestos toxicity in a transgenic model of malignant mesothelioma.FASEB bioAdvances · 2019Article
- HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Hepcidin mediated iron homoeostasis as immune regulator in visceral leishmaniasis patients.Parasite immunology · 2019Article
- MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin.Frontiers in cell and developmental biology · 2018Article
- Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis.Frontiers in immunology · 2017Review
- Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients.International journal of molecular sciences · 2016Article
- Hepcidin expression in psoriasis patients.Indian journal of dermatology · 2014Article
- Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Source of iron overload in multiple sclerosis.Cellular and molecular life sciences : CMLS · 2014Article
- Physiological implications of NTBI uptake by T lymphocytes.Frontiers in pharmacology · 2014Article
- Iron biology, immunology, aging, and obesity: four fields connected by the small peptide hormone hepcidin.Advances in nutrition (Bethesda, Md.) · 2013Review
- Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.PloS one · 2013Article
- [Anemia in patients with rheumatoid arthritis].Zeitschrift fur Rheumatologie · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepcidin regulates intracellular iron levels by interacting with and promoting the degradation of ferroportin, a membrane protein and the only known cellular iron exporter. Studies of hepcidin expression and regulation have focused on its effects in innate immunity and as a regulator of systemic iron metabolism. In the present study we characterized the expression of hepcidin messenger RNA (mRNA) in human peripheral blood mononuclear cells (PBMCs) with a focus on peripheral blood lymphocytes (PBLs). We found that (1) all human PBMCs analyzed express basal hepcidin mRNA levels; (2) hepcidin mRNA expression increases after T-lymphocyte activation; (3) expression by PBLs increases in response to challenge by holotransferrin (Fe-TF) and by ferric citrate in vitro; (4) the Fe-TF-mediated up-regulation of hepcidin decreases ferroportin expression at the cytoplasmic membrane of PBLs; and (5) silencing of tumour necrosis factor-alpha (TNF-alpha) abrogates the effect of Fe-TF. In summary, we show that hepcidin expression determines intracellular iron levels by regulating the expression of ferroportin, as described in other cells, and that inappropriately low expression of hepcidin impairs normal lymphocyte proliferation. The results establish hepcidin as a new player in lymphocyte biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.